Recruiting

HIIT

Sponsor:

Syracuse University

Code:

NCT05838950

Conditions

Obesity

Cardiovascular Diseases

Metabolic Disease

High-intensity Interval Training

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Not accepted

Interventions

high-intensity interval training intervention

Study Details

Brief summary:

The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.

Conditions

Obesity

Cardiovascular Diseases

Metabolic Disease

High-intensity Interval Training

Study ID

NCT05838950

Start date

Sep 29, 2023

Status verified date

Jul, 2025

Completion date

Dec 10, 2025

Anticipated

Primary completion date

Aug 23, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).

Exclusion Criteria:

  • Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
  • Taking weight loss medication(s)
  • Currently enrolled (or within previous 6 months) in a weight loss program;
  • An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
  • Presence of cardiac pacemaker.
  • Current or anticipated participation in another research that would interfere with any of the outcomes.
  • Current or anticipated pregnancy.

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: 5s HIIT

5s HIIT group will perform one bout of sprint running for 5-seconds followed by 25-second, resting of total 40 repetition.

experimental: 10s HIIT

10s HIIT group will perform one bout of sprint running for 10-seconds followed by 50-second, resting of total 20 repetition.

experimental: 20s HIIT

20s HIIT group will perform one bout of sprint running for 20-seconds followed by 100-second, resting of total 10 repetition.

experimental: Control

Control group

Interventions

high-intensity interval training intervention

Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.

Primary outcome measure

  • Height [ Time Frame: Baseline ]
  • Weight [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Body mass index [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Percentage body fat [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Fat mass [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Lean mass [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Systolic blood pressure [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Diastolic blood pressure [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Mean arterial pressure [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Flow-mediated dilation [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Carotid-femoral Pulse Wave Velocity (cPWV) [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Total cholesterol [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • LDL-C [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • HDL-C [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Triglycerides [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]
  • Glucose [ Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) ]

Central Contacts and Locations

Central contacts

Myong Won Seo, Ph.D

3154012723mseo04@syr.edu

Wonhee Cho, MS

6267270270mseo04@syr.edu

Locations

Women's Building

Recruiting

Syracuse, New York, United States, 13244

Contacts

Departments of Exercise Science

315-443-2115

More Information

Sponsor

Syracuse University

Last update posted

Jul 23, 2025

Last verified

Jul, 2025

Keywords

  • HIIT
  • Detraining effects
  • Cardiometabolic disease
  • Obesity
  • Young adults

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Syracuse University on 2025-07-23.