Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT05844865

Conditions

Peritoneal Carcinomatosis

Gastrointestinal Peritoneal Carcinomatosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection (Blood, Ascites/Peritoneal Wash Fluid and/or Tumor Samples)

Study Details

Brief summary:

This is a pilot study gathering and using samples and data from patients with gastrointestinal peritoneal carcinomatosis. Participants will be asked for permission to provide blood and ascites/peritoneal wash fluid, tumor samples during their planned surgical procedure.

Conditions

Peritoneal Carcinomatosis

Gastrointestinal Peritoneal Carcinomatosis

Study ID

NCT05844865

Start date

May 4, 2023

Status verified date

Aug, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients must have a GI tumor
  • Must have planned standard of care surgical procedure
  • Age ≥ 18 years.
  • Ability to understand and the willingness to sign a written informed consent

Exclusion Criteria:

\- Pattens who are unable to comply with the study protocol

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Subjects with Gastrointestinal Primary Tumor with or without Peritoneal Carcinomatosis

Subjects with gastrointestinal (GI) primary tumor with or without peritoneal carcinomatosis who are undergoing planned standard of care (SOC) surgical procedures. Biospecimens such as blood, peritoneal wash fluid and tumor samples will be obtained.

Interventions

Biospecimen Collection (Blood, Ascites/Peritoneal Wash Fluid and/or Tumor Samples)

Subjects with a known diagnosis of GI primary tumor with or without PC, with a planned standard of care surgery.

Primary outcome measure

  • Establishment of angioarchitechture of peritoneal lesions through Optical Coherence Tomography Angiography (OCTA) [ Time Frame: Up to 4 years ]
  • Development of individual patient-derived peritoneal carcinomatosis (pdPC) vascularized micro-tumor (VMT) [ Time Frame: Up to 4 years ]

Central Contacts and Locations

Central contacts

Chao Family Comprehensive Cancer Center University of California, Irvine

1-877-827-7883ucstudy@uci.edu

Locations

Chao Family Comprehensive Cancer Center, University of California, Irvine

Recruiting

Orange, California, United States, 92868

Contacts

Maheswari Senthil, MD FACS

877-827-8839ucstudy@uci.edu

More Information

Sponsor

University of California, Irvine

Last update posted

Aug 14, 2026

Last verified

Aug, 2026

Keywords

  • Peritoneal Carcinomatosis
  • Gastrointestinal Peritoneal Carcinomatosis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Irvine on 2026-08-14.