Recruiting

PICTURE IT & Lexical Treatment

Sponsor:

Johns Hopkins University

Code:

NCT05845047

Conditions

Aphasia

Stroke

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

PICTURE-IT

CoDeLT

Study Details

Brief summary:

The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.

Conditions

Aphasia

Stroke

Study ID

NCT05845047

Start date

May 31, 2023

Status verified date

Sep, 2026

Completion date

Oct, 2031

Anticipated

Primary completion date

Aug, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Age 18 or older
2. Premorbid proficiency in English
3. Left hemisphere ischemic or hemorrhagic stroke confirmed by imaging, which occurred either 1-4 months or ≥ 6 months ago
4. Diagnosis of aphasia secondary to stroke as defined using the Western Aphasia Battery-Revised Aphasia Quotient < 93.8.
5. Capable of giving informed consent or indicating another to provide informed consent

Exclusion Criteria:

1. Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke
2. Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders)
3. Inability to follow the treatment procedure as indicated by appropriate (not necessarily accurate) engagement during 5 probes of each.
4. Uncorrected severe visual loss or hearing loss by self-report and medical records

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: PICTURE IT Intervention-CoDeLT Intervention

Participants will receive PICTURE IT Intervention for 15 sessions followed by Computer Delivered Lexical Treatment (CoDeLT)Intervention for 15 sessions

active comparator: CoDeLT Intervention-PICTURE IT Intervention

Participants will receive Computer Delivered Lexical Treatment (CoDeLT) Intervention for 15 sessions followed by PICTURE IT Intervention for 15 sessions

Interventions

PICTURE-IT

The speech-language pathologist (SLP) will provide one of the following stimuli hierarchically:

1. Single words depicted in the picture, then with written and spoken labels
2. 2-word phrases depicted in the picture and then with written and spoken word
3. Subject-Verb-Object sentence depicted in the picture and then with written and spoken sentences
4. Two-sentence event, depicted with photos and subsequently with two written and spoken sentences
5. Short story depicted with a video clip and subsequently with printed and spoken narrative.

Sessions will be completed online with a speech-language pathologist using video conferencing software, using a laptop and a hot spot the investigators will provide if needed. Participants in both groups will receive the same 15 45-minute sessions of a PICTURE-IT.

CoDeLT

The speech-language pathologist (SLP) will facilitate the computer-delivered naming treatment, consisting of a picture/seen and heard spoken word verification task.

A picture will be presented for two seconds on a laptop computer screen and will be immediately followed by an audio-visual display of a speaker's mouth saying a noun, phrase, or sentence. The spoken word, phrase, or sentence either will or will not fit the preceding picture, and the participant must indicate whether the picture and video match or do not match. The computer will provide immediate visual feedback following a response.

Sessions will be completed online with a speech-language pathologist using video conferencing software, using a laptop and a hot spot the investigators will provide if needed. Participants in both groups will receive the same 15 45-minute sessions of a PICTURE-IT.

Primary outcome measure

  • Change in discourse content as assessed by z-score for the number of meaning-carrying units used in describing a picture [ Time Frame: Baseline, 1 week after treatment ]

Central Contacts and Locations

Central contacts

Argye E Hillis, MD

410-614-2381argye@jhmi.edu

Melissa D Stockbridge, PhD

md.stockbridge@jhmi.edu

Locations

Johns Hopkins School of Medicine

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Argye E Hillis, MD

410-614-2381argye@jhmi.edu

Melissa D Stockbridge, PhD

md.stockbridge@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Sep 8, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-09-08.