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Not recruiting

Observational Study

Sponsor:

University of Pennsylvania

Code:

NCT05850676

Conditions

Hypersomnia

Eligibility Criteria

Sex: All

Age: 21 - 55

Healthy Volunteers: Not accepted

Interventions

Sleep study

Study Details

Brief summary:

Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.

Conditions

Hypersomnia

Study ID

NCT05850676

Start date

Aug 1, 2023

Status verified date

Aug, 2026

Completion date

Aug 3, 2026

Primary completion date

Aug 3, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Males and females between the age of 21 and 55
  • Meet DSM5 criteria for Idiopathic Hypersomnia or Hypersomnia Associated with a Psychiatry Disorder
  • Ability to read and speak English

Exclusion Criteria:

  • Unable or unwilling to provide informed consent
  • Untreated obstructive sleep apnea (apnea-hypopnea index /= 15 events/hr)
  • Meeting diagnostic criteria for narcolepsy
  • A clinically unstable medical condition as defined by a new diagnosis or change in medical management in the previous 2 months (e.g., pneumonia, thyroid disease, ventricular arrhythmias, cirrhosis, surgery, or recently diagnosed cancer) because these changes could impact daytime hypersomnia and confound results
  • Substance abuse/dependence, delirium, dementia, amnestic disorder, schizophrenia, and other psychotic disorders
  • Prominent current suicidal or homicidal ideation.
  • Unable to perform tests due to inability to communicate verbally, inability to read and write; less than a 5th grade reading level; visal, hearing, or cognitive impairment (e.g. previous head injury)
  • Use of medications or OTC products that might impact sleep

Study Design

Enrollment

54 participants

Interventions and Outcome Measures

Arms

Idiopathic Hypersomnia

Men and women with a current diagnosis of Idiopathic Hypersomnia

Hypersomnia Associated with a Psychiatric Disorder

Men and women with a current diagnosis of Hypersomnia Associated with a Psychiatric Disorder

Interventions

Sleep study

Participants will spend two nights in the Penn Sleep Center

Primary outcome measure

  • Depression severity [ Time Frame: One time at baseline ]

Central Contacts and Locations

More Information

Sponsor

University of Pennsylvania

Last update posted

Aug 6, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2026-08-06.