Recruiting

Opioid Cessation

Sponsor:

Mayo Clinic

Code:

NCT05854303

Conditions

Opioid-Induced Esophageal Dysfunction

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Opioid cessation

No opioid cessation

Study Details

Brief summary:

The purpose of this study is to evaluate the effect of opioid cessation on opioid-induced esophageal dysfunction (OIED).

Conditions

Opioid-Induced Esophageal Dysfunction

Study ID

NCT05854303

Start date

Sep 18, 2023

Status verified date

Oct, 2025

Completion date

Nov, 2026

Anticipated

Primary completion date

Nov, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

\- Patients enrolled in the Pain Rehabilitation Center for opioid cessation, with or without esophageal symptoms.

Exclusion Criteria:

  • Inability to provide informed consent.
  • Patients with previous gastroesophageal surgery or pneumatic dilation.
  • Esophageal botulinum toxin injection within the prior 12 months.
  • Esophageal stricture
  • Achalasia types I and II
  • Allergy to Lidocaine or other local anesthetics
  • Subjects on anticoagulation
  • Bilateral nasal obstruction
  • Pregnancy or breast feeding

Study Design

Enrollment

26 participants

Anticipated

Interventions and Outcome Measures

Arms

Opioid Cessation

Subjects able to complete opioid cessation.

Non-Opioid Cessation

Subjects unable to complete opioid cessation.

Interventions

Opioid cessation

opioid cessation will occur during pain rehabilitative program over approximately 3 weeks

No opioid cessation

Subjects will not stop taking opioids

Primary outcome measure

  • Number of subjects to have opioid-induced esophageal dysfunction resolution [ Time Frame: 4 weeks ]

Central Contacts and Locations

Central contacts

Mariah Robran

507-266-3595robran.mariah@mayo.edu

Locations

Mayo Clinic Minnesota

Recruiting

Rochester, Minnesota, United States, 55905

More Information

Sponsor

Mayo Clinic

Last update posted

Oct 16, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2025-10-16.