Recruiting

Observational Study

Sponsor:

Tufts Medical Center

Code:

NCT05866952

Conditions

Post-Acute COVID-19

Post COVID-19 Condition

Post Viral Fatigue

Dyspnea

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Computed Tomography of the Chest

Study Details

Brief summary:

Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations

Conditions

Post-Acute COVID-19

Post COVID-19 Condition

Post Viral Fatigue

Dyspnea

Study ID

NCT05866952

Start date

Jun 5, 2023

Status verified date

Jul, 2025

Completion date

Dec 31, 2026

Anticipated

Primary completion date

May 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age ≥ 18
  • Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing > 3 months ago or no previous history of SARS-CoV-2 infection (control group only)
  • Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
  • New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)

Exclusion Criteria:

  • SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months
  • Inability to provide consent or non-English speaking
  • Pregnancy
  • Any respiratory infection in last 4 weeks
  • PFT relative contraindications
  • History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
  • Active malignancy undergoing treatment or history of malignancy involving the lung

Study Design

Enrollment

40 participants

Anticipated

Interventions and Outcome Measures

Arms

Post-Acute Sequelae of SARS-CoV-2 (PASC) Group

Subjects with PASC with a documented history of COVID-19 and persistent symptoms of fatigue, dyspnea, and/or exercise intolerance

Control: Fully recovered COVID-19

Subjects with a history of COVID-19 who have fully recovered from COVID-19 with no post-acute sequelae of SARS-Cov-2

Control: No history of COVID-19

Healthy subjects without a documented history of COVID-19, no current symptoms, and a normal baseline High resolution CT of the chest

Interventions

Computed Tomography of the Chest

Quantitative Computed Tomography of the chest in the inspiratory and expiratory phases will be performed to assess regional lung ventilation as well as pulmonary vascular volume and distribution

Primary outcome measure

  • Measures of regional lung ventilation [ Time Frame: 1 day ]
  • Measures of blood volume distribution [ Time Frame: 1 day ]

Central Contacts and Locations

Central contacts

Bipin Malla

617-636-6304tuftsmccorstudy@tuftsmedicalcenter.org

Locations

Tufts Medical Center

Recruiting

Boston, Massachusetts, United States, 02111

Principal Investigator:

Maher Ghamloush, MD

More Information

Sponsor

Tufts Medical Center

Last update posted

Jul 20, 2025

Last verified

Jul, 2025

Keywords

  • Ventilation Perfusion Mismatch

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Tufts Medical Center on 2025-07-20.