Recruiting

Premedication

Sponsor:

Salem Anaesthesia Pain Clinic

Code:

NCT05876117

Conditions

Claustrophobia

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Claustrophobia is an irrational fear of restriction and suffocation. It is a specific phobia, according to DSM 5. Claustrophobic patients may fear that restriction of their limbs will hinder their ability to move quickly towards safety. MRI may trigger claustrophobia, because this diagnostic procedure involves a patient laying in a narrow tube. Premedication before MRI scan may occasionally reduce claustrophobia.

Prospective observational crossover study of claustrophobic patients who are undergoing MRI scan. At alternate MRI scan sessions, each patient receives rotational premedication using Lorazepam 1mg; or Clonidine tablet 0.2mg; or combined Clonidine 0.2mg + Lorazepam 1mg.

Patient will use Claustrophobia Questionnaire, a validated tool, to collect data on the days before and after each MRI scan. CLQ is a patient-administered tool used to assess claustrophobia. In addition, patient will use General Anxiety Disorder Questionnaire, a validated tool, to collect data on the days before and after each MRI scan. GAD-7 is a patient-administered tool that is used to assess anxiety.

Conditions

Claustrophobia

Study ID

NCT05876117

Start date

Jul 4, 2020

Status verified date

Jan, 2025

Completion date

Dec 31, 2025

Anticipated

Primary completion date

Dec 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • diagnosed with claustrophobia
  • previous incomplete MRI because of claustrophobia
  • adult patients
  • good treatment compliance
  • reliable Claustrophobia Questionnaire (CLQ) diary
  • reliable General Anxiety Disorder Questionnaire (GAD) diary
  • informed consent for diary review
  • consent for clinical record quality assurance review

Exclusion Criteria:

  • poor treatment compliance
  • cognitive disorder
  • inability to provide consent
  • major neuropsychiatric disorder
  • unreliable diary
  • cannabis use
  • excessive alcohol intake
  • previous adverse/allergic reactions to clonidine
  • previous adverse/allergic reactions to lorazepam

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Claustrophobic adult patients

Claustrophobic adult patients who are undergoing MRI scan as part of chronic pain management.

Primary outcome measure

  • Rate of completion of MRI scan [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

Locations

Salem Anaesthesia Pain Clinic

Recruiting

Surrey, British Columbia, Canada, V3S 7J1

Contacts

More Information

Sponsor

Salem Anaesthesia Pain Clinic

Last update posted

Jan 27, 2025

Last verified

Jan, 2025

Keywords

  • Claustrophobia MRI

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Salem Anaesthesia Pain Clinic on 2025-01-27.