Recruiting

Astaxanthin

Sponsor:

Integrative Skin Science and Research

Code:

NCT05882084

Conditions

Photoaging

Eligibility Criteria

Sex: Female

Age: 30 - 55

Healthy Volunteers: Accepted

Interventions

Astaxanthin 6 mg daily

Placebo

Study Details

Brief summary:

This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.

Conditions

Photoaging

Study ID

NCT05882084

Start date

Jul 24, 2023

Status verified date

Jul, 2023

Completion date

Dec 31, 2023

Anticipated

Primary completion date

Sep 30, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 30 - 55

Healthy Volunteers: Accepted

Inclusion criteria:

  • Females who are 30 to 55 years of age
  • Half of the women will have Fitzpatrick skin type 1-3 and the other half of the women will have Fitzpatrick skin type 4-6

Exclusion criteria:

  • Individuals with a known allergy to astaxanthin or other carotenoids (such as zeaxanthin, lutein, lycopene).
  • Individuals who are unwilling to discontinue carotenoid supplementation for at least 1 month prior to enrollment
  • Individuals unwilling to restrict intake of foods like shrimp, salmon, mangos, carrots, and tomatoes during the study.
  • New supplementation within 4 weeks with tocopherol
  • Individuals who are unwilling to stay consistent with a facial cleansing regimen.
  • Those who are unwilling to discontinue topical hydroquinone, retinoid or benzoyl peroxide for 2 weeks prior to enrollment
  • Individuals who are pregnant or breastfeeding.
  • Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.
  • Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Astaxanthin

6 mg daily

placebo comparator: Placebo

Interventions

Astaxanthin 6 mg daily

Astaxanthin at 6 mg is given for daily ingestion and compared against placebo.

Placebo

Placebo

Primary outcome measure

  • Skin Hydration [ Time Frame: 8 weeks ]
  • Skin elasticity [ Time Frame: 8 weeks ]

Central Contacts and Locations

Central contacts

Raja Sivamani, MD

916-524-1216research@integrativeskinresearch.com

Locations

Integrative Skin Science and Research

Recruiting

Sacramento, California, United States, 95819

Contacts

Nasima Afzal

916-750-2463nasima@integrativeskinresearch.com

More Information

Sponsor

Integrative Skin Science and Research

Last update posted

Jul 25, 2023

Last verified

Jul, 2023

Keywords

  • Carotenoid
  • Astaxanthin
  • Skin
  • Hydration
  • Elasticity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Integrative Skin Science and Research on 2023-07-25.