Recruiting

Lung Cancer Screening

Sponsor:

Massachusetts General Hospital

Code:

NCT05898594

Conditions

Lung Cancer

Lung Carcinoma

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Interventions

Low-dose Computed Tomography

Study Details

Brief summary:

The goal of this research study is to study U.S. Black individuals with a history of smoking to examine the feasibility, acceptability, and performance of low-dose computed tomography (LDCT) screening among this population.

The name of the intervention used in this research study is:

Low-dose computed tomography (radiologic scan) chest scan

Conditions

Lung Cancer

Lung Carcinoma

Study ID

NCT05898594

Start date

Sep 6, 2023

Status verified date

Feb, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Jun 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Self-identified Black individual.
  • Have a self-reported history of smoking. No restriction will be placed on the number of smoking pack years participants must have nor the number of years former smokers must have quit smoking.
  • Aged 50-80 years.

Exclusion Criteria:

  • Individuals with a history of lung cancer.
  • Individuals with symptoms suggestive of lung cancer. We will evaluate whether individuals have symptoms suggestive of lung cancer by administering an online screening questionnaire, which will ask whether they have experienced shortness of breath, whether they become easily winded, and whether they have had a chronic cough within the last 12 weeks that has not improved. Individuals who select that they have any one of these symptoms will be advised to follow up with their primary doctor and will not be eligible to participate in the study.
  • Individuals with pneumonia or acute respiratory infection within 12 weeks prior to enrollment that was treated with antibiotics.

Study Design

Enrollment

900 participants

Anticipated

Intervention Model

Single group

Primary purpose

Screening

Interventions and Outcome Measures

Arms

experimental: Screening: Low-Dose Computed Tomography Screening

Participants will undergo study procedures as outlined:

  • Complete questionnaires pre- and post- low-dose computed tomography (LDCT) test.
  • Visit Massachusetts General Hospital facility for a LDCT screening test.

Interventions

Low-dose Computed Tomography

Per standard care

Primary outcome measure

  • Proportion of Enrolled Participants [ Time Frame: At enrollment ]
  • Proportion of Participants with Positive Low-dose Computed Tomography Test [ Time Frame: At 3 months ]
  • Proportion of Participants Diagnosed with Invasive Lung Cancer [ Time Frame: At 6 months ]
  • Distribution of Lung Imaging Reporting and Data System (Lung-RADS) Scores [ Time Frame: At 3 months ]

Central Contacts and Locations

Central contacts

Chi Fu Jeffrey Yang, MD

617-724-1681cjyang@mgh.harvard.edu

Locations

University of Chicago

Recruiting

Chicago, Illinois, United States, 60637

Contacts

Jessica Donington, MD

773-834-6121jdonington@surgery.bsd.uchicago.edu

Massachusetts General Hospital Cancer Center

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Chi Fu Jeffrey Yang, MD

617-724-1681cjyang@mgh.harvard.edu

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Feb 23, 2026

Last verified

Feb, 2026

Keywords

  • Lung Cancer
  • Lung Carcinoma

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-02-23.