Recruiting

Observational Study

Sponsor:

Medical College of Wisconsin

Code:

NCT05914987

Conditions

Pancreatic Neoplasms

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Targeted Therapy

Study Details

Brief summary:

This is a non-therapeutic exploratory observational precision oncology study designed to collect and analyze data that demonstrate the clinical efficacy and tolerability of personalized treatments based on molecular tumor profiling assessments (i.e., matched therapy) in adult pancreatic cancer patients. Patient medical records, obtained both retrospectively and prospectively, will be examined for results of molecular profiling obtained through standard of care testing to help understand how well molecular testing might predicts response to therapy. Patient demographic and outcome parameters to be evaluated include, but are not limited to, tumor response, time to treatment failure, patient survival, and toxicity.

Conditions

Pancreatic Neoplasms

Study ID

NCT05914987

Start date

Dec 4, 2023

Status verified date

Apr, 2026

Completion date

Aug 1, 2033

Anticipated

Primary completion date

Aug 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥18 years.
  • Pathologically confirmed pancreatic cancer.
  • Ability to understand a written informed consent document and the willingness to sign it

Exclusion Criteria:

  • Age <18 years.
  • Primary cancer diagnosis other than pancreatic cancer.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Interventions

Targeted Therapy

Approved interventions based on the subject's genomic profile will be provided to investigators for consideration for anti-tumor therapy.

Primary outcome measure

  • Number of Subjects Receiving Targeted Therapy [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Cancer Center Clinical Trials Office

1-414-805-8900cccto@mcw.edu

Locations

Froedtert Hospital and the Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Mandana Kamgar, MD

414-805-8900mkamgar@mcw.edu

More Information

Sponsor

Medical College of Wisconsin

Last update posted

May 5, 2026

Last verified

Apr, 2026

Keywords

  • Mutation
  • Genomics
  • Targeted Therapy
  • Cancer
  • Pancreas

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medical College of Wisconsin on 2026-05-05.