Recruiting

Circadian Intervention

Sponsor:

University of Utah

Code:

NCT05943626

Conditions

Cardiometabolic Syndrome

Type 2 Diabetes

Sleep

Time Restricted Feeding

Lifestyle Factors

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Circadian Intervention

Study Details

Brief summary:

The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian intervention is designed to reduce nighttime light exposure and after-dinner snack food intake. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).

Conditions

Cardiometabolic Syndrome

Type 2 Diabetes

Sleep

Time Restricted Feeding

Lifestyle Factors

Study ID

NCT05943626

Start date

Jun 13, 2023

Status verified date

Aug, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Age: 18-45 years old; equal numbers of men and women
2. Body mass index (BMI): 25.0-34.9 kg/m2,
3. Sleep Habits: habitual self-reported average total sleep time (TST) <6.5 hours per night for prior 6 months

Exclusion Criteria:

1. Clinically diagnosed sleep disorder or major psychiatric illness
2. Evidence of significant organ dysfunction or disease (e.g., diagnosed diabetes, cardiovascular disease, or kidney disease)
3. Use of prescription drugs or substances known to influence sleep or glucose metabolism
4. Shift-work: current or history of within last year
5. Weight change: >10% of body weight over prior six months
6. Experiencing menopause or post-menopausal
7. Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program
8. Currently pregnant or planning to become pregnant, or currently lactating.
9. Currently smoking
10. Alcohol intake >3 drinks per day or >14 drinks per week

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

no intervention: Control Group

Provided with general health information on diet and physical activity.

experimental: Intervention Group

Circadian-based intervention focused on timing of light exposure and food intake.

Interventions

Circadian Intervention

The circadian intervention group will receive counseling and instruction to reduce evening and nighttime light exposure, increase morning room light and sunlight exposure, and to finish all food consumption at least 4 hours before bedtime.

Primary outcome measure

  • Insulin sensitivity change from baseline [ Time Frame: Change from baseline to end of the ~8 week experimental segment ]

Central Contacts and Locations

Central contacts

Christopher M Depner, PhD

801-581-2275christopher.depner@utah.edu

Locations

College of Health Research Complex--University of Utah

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Christopher Depner

8015812275sleepstudyparticipant@utah.edu

More Information

Sponsor

University of Utah

Last update posted

Aug 5, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-10. This information was provided to ClinicalTrials.gov by University of Utah on 2026-08-05. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.