Recruiting

Beetroot Juice

Sponsor:

Pepperdine University

Code:

NCT05957835

Conditions

High Nitrate Dose

Moderate Nitrate Dose

Low Nitrate Dose

Nitrate-depleted Dose

Eligibility Criteria

Sex: Male

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

BR-HIGH

BR-MOD

BR-LOW

PL

Study Details

Brief summary:

Dietary nitrate supplementation, administered in the form of nitrate-rich beetroot juice, has been shown to improve exercise performance and may have more pronounced effects on exercise that requires high-power and high-velocity muscle contraction such as weightlifting and body-mass resisted exercise (i.e, resistance exercise). However, limited data are available that have examined the potential performance enhancing effect of beetroot juice in resistance exercise. Moreover, there is no information on the dose of nitrate required for performance enhancing effects during resistance exercise which limits its widespread use to enhance performance. Therefore, the investigators will assess if supplementing the diet with nitrate-rich beetroot juice impacts resistance exercise performance (e.g., power, velocity), when compared to supplementing the diet with nitrate-depleted beetroot juice (i.e. placebo). The investigators will also investigate the dose-response effect of beetroot juice on resistance exercise performance by providing a low, moderate, and high nitrate dose of concentrated beetroot juice. The results of this study will improve understanding of whether beetroot juice influences resistance exercise performance and will provide insight on whether different doses of beetroot juice influence the efficacy of nitrate supplementation on resistance exercise performance. Together, these data will guide supplementation strategies for enhancing resistance exercise performance.

Conditions

High Nitrate Dose

Moderate Nitrate Dose

Low Nitrate Dose

Nitrate-depleted Dose

Study ID

NCT05957835

Start date

May 23, 2023

Status verified date

Jun, 2023

Completion date

Jun 30, 2024

Anticipated

Primary completion date

Apr 28, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Recreationally active males who performed resistance exercise at least twice weekly for the last two years

Exclusion Criteria:

  • individuals with contraindications to exercise, cardiometabolic disease, currently consuming dietary supplements containing caffeine, sodium bicarbonate, creatine, beta-alanine, and/or NO precursor supplements (i.e., NO3-, arginine, citrulline, antioxidants), females, and smokers

Study Design

Enrollment

18 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: BR-HIGH

Participants will ingest an elevated dose of nitrate 2.5 hours prior to exercise.

experimental: BR-MOD

Participants will ingest a moderate dose of nitrate 2.5 hours prior to exercise.

experimental: BR-LOW

Participants will ingest a low dose of nitrate 2.5 hours prior to exercise.

placebo comparator: PL

Participants will ingest a negligible amount of nitrate 2.5 hours prior to exercise.

Interventions

BR-HIGH

4 x nitrate-rich beetroot juice shots (26 mmol of nitrate)

BR-MOD

2 x nitrate-rich beetroot juice shots + 2 x nitrate-depleted beetroot juice shot (12 mmol of nitrate)

BR-LOW

1 x nitrate-rich beetroot juice shot + 3 x nitrate-depleted beetroot juice shots (6 mmol of nitrate)

PL

4 x nitrate-depleted beetroot juice shots (0 mmol of nitrate)

Primary outcome measure

  • Plasma nitrate [ Time Frame: Through study completion, at least 1 year ]
  • Plasma nitrite [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Neuromuscular performance during countermovement jumps [ Time Frame: Through study completion, at least 1 year ]
  • Peak power [ Time Frame: Through study completion, at least 1 year ]
  • Mean power [ Time Frame: Through study completion, at least 1 year ]
  • Mean velocity [ Time Frame: Through study completion, at least 1 year ]
  • Peak velocity [ Time Frame: Through study completion, at least 1 year ]

Central Contacts and Locations

Locations

Pepperdine University

Recruiting

Malibu, California, United States, 90263

Contacts

More Information

Sponsor

Pepperdine University

Last update posted

Jul 24, 2023

Last verified

Jun, 2023

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Pepperdine University on 2023-07-24.