Recruiting
Phase 1

Observational Study

Sponsor:

Stanford University

Code:

NCT05962424

Conditions

Psychiatric Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ketamine Hydrochloride

Study Details

Brief summary:

The purpose of this study is to understand how ketamine brings about dissociative symptoms.

Conditions

Psychiatric Disorder

Study ID

NCT05962424

Start date

Oct 5, 2023

Status verified date

Apr, 2026

Completion date

Sep 1, 2030

Anticipated

Primary completion date

Sep 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient in clinical neuro inpatient units at Stanford Medical Center
  • Age >18 years old
  • Female participants are expected to use an effective method of birth control throughout the study which includes: hormonal methods (birth control pills, patches, injections, vaginal ring or implants), barrier methods (condom or diaphragm) used with spermicide, intrauterine device (IUD), or abstinence (no sex)

Exclusion Criteria:

  • Lifetime psychotic disorder
  • Pregnant or nursing females
  • Prior adverse ketamine response
  • Use of ketamine in past 7 days

Study Design

Enrollment

120 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Ketamine

Study participants will receive 0.5mg/kg of ketamine - one single infusion

Interventions

Ketamine Hydrochloride

Ketamine is an FDA-approved dissociative anesthetic.

Primary outcome measure

  • Number of participants with dissociative events during ketamine infusion as assessed by CADSS (Clinician-Administered Dissociative State Scale) [ Time Frame: up to 1 week ]

Central Contacts and Locations

Central contacts

Arjay Cordero

650-580-9000arjayc@stanford.edu

Locations

Stanford University

Recruiting

Palo Alto, California, United States, 94306

More Information

Sponsor

Stanford University

Last update posted

Apr 22, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stanford University on 2026-04-22.