Recruiting

Transdiagnostic Intervention

Sponsor:

Massachusetts General Hospital

Code:

NCT05962879

Conditions

Anxiety Disorders

Psychotic Disorders

Depressive Disorder

Psychosocial Functioning

Eligibility Criteria

Sex: All

Age: 14 - 19

Healthy Volunteers: Not accepted

Interventions

Resilience Training for Teens

Study Details

Brief summary:

This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.

Conditions

Anxiety Disorders

Psychotic Disorders

Depressive Disorder

Psychosocial Functioning

Study ID

NCT05962879

Start date

Mar 22, 2024

Status verified date

Jun, 2026

Completion date

May 31, 2027

Anticipated

Primary completion date

May 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 14 - 19

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Currently enrolled in 9th through 12th grade and between the ages of 14 and 19
  • Endorsed at least one psychotic experience
  • Provided contact information
  • Have a parent or legal guardian who is able and willing to provide written informed consent (if under the age of 18)
  • Have a parent or legal guardian who is able and willing to participate in a parent session
  • Competent and willing to provide written informed assent (if under the age of 18) or consent (if age 18 or older)
  • Able to communicate in English

Exclusion Criteria:

  • Currently prescribed psychotropic medication (not including medications for attention deficit/hyperactivity disorder), regardless of adherence
  • Currently obtaining psychotherapeutic intervention

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Resilience Training for Teens

A brief 6-session group-based behavioral intervention for teens at risk of a mental illness.

no intervention: Waitlist

A one year waitlist period where participants will not participate in Resilience Training for Teens. Following that one year waitlist period, they can participate in Resilience Training for Teens.

Interventions

Resilience Training for Teens

A brief 6-session group-based behavioral intervention for high school aged teenagers at risk of a mental illness.

Primary outcome measure

  • Structured Interview of Psychosis-risk Syndromes (SIPS) [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Nicole R DeTore, PhD

617-726-2065ndetore@mgh.harvard.edu

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Nicole R DeTore, PhD

ndetore@mgh.harvard.edu

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Jun 11, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-06-11.