Recruiting

QL Block

Sponsor:

Joseph Findley MD

Code:

NCT05979493

Conditions

Postoperative Pain

Fibroid Uterus

Eligibility Criteria

Sex: Female

Age: 18 - 45

Healthy Volunteers: Not accepted

Interventions

Bupivacain

Saline

Study Details

Brief summary:

This study aims to determine the efficacy of a quadratus lumborum (QL) block in decreasing postoperative pain in patients undergoing myomectomy for uterine fibroids. A QL block is a temporary anesthetic injection in the quadratus lumborum muscle, a muscle in the lower back, that has been previously shown to significantly reduce postoperative pain levels in patients undergoing abdominal and pelvic surgery. Because of its demonstrated effects, the QL block is becoming a standard of anesthesia and surgical care. Since participants will be undergoing a myomectomy procedure, the investigators believe that participants may qualify to participate in this study. The investigators will be comparing patients who receive the QL block (in addition to standard anesthesia and postoperative pain care) with patients who do not receive the QL block (in addition to standard care). The participants will be randomly assigned to one of the two groups and may or may not actually receive the block.

Conditions

Postoperative Pain

Fibroid Uterus

Study ID

NCT05979493

Start date

Aug 24, 2024

Status verified date

Jul, 2026

Completion date

Jul 3, 2028

Anticipated

Primary completion date

Jul 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 45

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Presence of uterine fibroids requiring surgical excision with preservation of the uterus
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Provision of signed and dated informed consent form

Exclusion Criteria:

  • Pre-existing diagnoses of anxiety or depression
  • Pre-existing coagulopathies
  • Pre-existing neuropathic or chronic pelvic pain
  • Chronic opioid use
  • Illiteracy due to inability to read and understand plain questionnaire
  • Non-English speaking
  • BMI >38

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: QL Block with Bupivacaine

Participants will get a QL block using 30cc Bupivacaine bilaterally in quadratus lumborum muscle (60cc total).

sham comparator: Control

Participants will get a sham injection of 30cc saline bilaterally in quadratus lumborum muscle (60cc total).

Interventions

Bupivacain

30cc IM injection in each quadratus lumborum muscle (60cc total).

Saline

30cc IM injection in each quadratus lumborum muscle (60cc total).

Primary outcome measure

  • Time in minutes from first analgesic request as measured by medical chart review [ Time Frame: Up to 24 hours ]
  • Total number of doses of rescue analgesics given as measured by medical chart review [ Time Frame: Up to 24 hours ]

Central Contacts and Locations

Central contacts

Catherine P Haering, BA

3392011531cph43@case.edu

Locations

University Hospitals Ahuja Medical Center

Recruiting

Beachwood, Ohio, United States, 44122

Contacts

Catherine P Haering, BA

3392011531cph43@case.edu

More Information

Sponsor

Joseph Findley MD

Last update posted

Sep 11, 2026

Last verified

Jul, 2026

Keywords

  • QL Block
  • Myomectomy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-09. This information was provided to ClinicalTrials.gov by Joseph Findley MD on 2026-09-11. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.