Recruiting

Visuomotor Training

Sponsor:

VA Office of Research and Development

Code:

NCT05983185

Conditions

Spatial Neglect After Right Brain Stroke

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Prism adaptation therapy

Study Details

Brief summary:

After a right brain stroke, >50% of Veterans experience problems with dressing, eating, self-care or steering their wheelchairs because their ability to move, orient, and respond toward the left side is limited: spatial neglect. Spatial neglect prevents them from functioning independently, and their needs in the hospital and at home are greatly increased. An effective treatment for spatial neglect is 10 days of visuomotor training while wearing optical prisms (PAT), however many clinicians \[fail to diagnose spatial neglect and use this approach. In this study, the investigators will develop a brain scanning test that could objectively identify the Veterans with spatial neglect after stroke who are the best candidates to receive PAT and recover their ability to function. When the research is complete, the investigators expect that brain scans done in the hospital can guide the team to refer Veterans to PAT rehabilitation: improving daily life function\] and quality of life.

Conditions

Spatial Neglect After Right Brain Stroke

Study ID

NCT05983185

Start date

Feb 1, 2023

Status verified date

Apr, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Has had a first right brain stroke >18 years of age
  • 1-4 months post-diagnosis of right brain stroke
  • Can sit up, see out of both eyes and point to objects (>20/50 vision in both eyes)
  • Can give informed consent to participate

Exclusion Criteria:

  • Has been diagnosed with other chronic, disabling neurological disorder (e.g. multiple sclerosis, Alzheimer Disease)
  • Has had a clinical left brain stroke or has neuroimaging evidence of prior stroke(s) including the presence of more than two lacunes with diameter greater than 15 mm.
  • Cannot sit up to be tested and receive PAT
  • Has <20/50 vision when viewing with both eyes

Study Design

Enrollment

244 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

active comparator: Prism adaptation Therapy

People with spatial neglect will receive this effective treatment to reduce symptoms, which the investigators' previous work indicated may be particularly effective for Aiming SN symptoms.

no intervention: No spatial neglect

People without spatial neglect symptoms will not receive an intervention for spatial neglect.

Interventions

Prism adaptation therapy

The investigators' research and clinical group is the US leader in implementing this intervention for spatial neglect and have brought it to more than 50 clinical centers, hospitals, and treatment organizations.

Primary outcome measure

  • Spatial neglect (SN) type (Aiming SN versus Where SN) [ Time Frame: baseline ]
  • Functional independence Measure (FIM) improvement trajectory [ Time Frame: 5 weeks after enrollment ]

Central Contacts and Locations

Central contacts

Locations

VA Connecticut Healthcare System West Haven Campus, West Haven, CT

Recruiting

West Haven, Connecticut, United States, 06516-2770

Contacts

Atlanta VA Medical and Rehab Center, Decatur, GA

Recruiting

Decatur, Georgia, United States, 30033-4004

Contacts

VA Central Western Massachusetts Healthcare System, Leeds, MA

Recruiting

Leeds, Massachusetts, United States, 01053-9764

Contacts

Principal Investigator:

Anna M. Barrett, MD

Louis Stokes VA Medical Center, Cleveland, OH

Recruiting

Cleveland, Ohio, United States, 44106-1702

Contacts

More Information

Sponsor

VA Office of Research and Development

Last update posted

Apr 23, 2026

Last verified

Apr, 2026

Keywords

  • spatial neglect
  • cognition
  • stroke rehabilitation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by VA Office of Research and Development on 2026-04-23.