Recruiting

PET vs. Cardiac CT

Sponsor:

Johns Hopkins University

Code:

NCT05994014

Conditions

Coronary Artery Disease

Atherosclerosis

Coronary Atherosclerosis of Native Coronary Artery

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

PET/CT

Study Details

Brief summary:

Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resolution-CT (UHR-CT) in patients with suspected coronary artery disease. For this purpose, the investigators plan to include 33 patients with symptoms concerning for CAD who have been referred for cardiac CT testing.

Conditions

Coronary Artery Disease

Atherosclerosis

Coronary Atherosclerosis of Native Coronary Artery

Study ID

NCT05994014

Start date

Jul 1, 2023

Status verified date

Jun, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Male or female patients
  • 18 years or older
  • referred for coronary CT angiography because of suspected coronary heart disease (CHD) with stable symptoms

Exclusion Criteria:

  • The patient has a history of coronary heart disease, defined by prior myocardial infarction or prior coronary artery revascularization.
  • Pregnancy.
  • Atrial fibrillation.
  • Morbid obesity defines as a body mass index of >40.
  • The patient has any other clinically significant medical condition that in the opinion of the Investigator could impact the patient's ability to successfully complete the trial.

Study Design

Enrollment

33 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

other: Main group

All patients undergo both, experimental and standard, tests

Interventions

PET/CT

Experimental test for detecting atherosclerosis

Primary outcome measure

  • Correlation of atheroma volume [mm3] [ Time Frame: 60 days ]
  • Diagnostic accuracy of detecting coronary atherosclerosis [ Time Frame: 60 days ]

Central Contacts and Locations

Central contacts

Armin A Zadeh, MD PhD MPH

410-502-0549azadeh1@jhmi.edu

Tia Thomas, RN, BSN

410-955-5000tthoma88@jh.edu

Locations

Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21287

Principal Investigator:

Armin A Zadeh, MD

More Information

Sponsor

Johns Hopkins University

Last update posted

Jun 9, 2026

Last verified

Jun, 2026

Keywords

  • coronary imaging
  • prevention
  • early detection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-06-09.