Recruiting
Phase 1

Vaping Cessation

Sponsor:

Washington University School of Medicine

Code:

NCT05994209

Conditions

Nicotine Vaping

Nicotine Use Disorder

Eligibility Criteria

Sex: All

Age: 15 - 25

Healthy Volunteers: Not accepted

Interventions

quitSTART Mobile Application

Chatbot Feature in quitSTART Mobile Application

Study Details

Brief summary:

Use of vaping products (e.g., electronic nicotine delivery systems, e-cigarettes) has been increasing rapidly, particularly among teens and young adults. With limited information on the long-term effects of vaping products, health information about vaping has been somewhat unclear in regards to associated health risks. Teens and young adults may be reluctant to disclose their use of vaping products to parents or health providers and instead turn to social media to share and seek out information regarding vaping risks and cessation supports. Thus, our current proposal outlines the use of social media to identify teens and young adults socially networking about vaping, the use of an online chatbot screen to evaluate individual cessation support needs, and the use of a digital intervention system to support vaping cessation. The mobile intervention used in this study is based on a widely-used evidence-based mobile intervention for combustible smoking (i.e., quitSTART) and has been adapted for vaping and young adults to include an in-app chatbot to guide users to tailored content and to motivate and encourage their cessation efforts. We aim to integrate our social media recruitment and online screening approach to connect individuals with this mobile app intervention, and will conduct a randomized controlled trial to evaluate user engagement with and preliminary efficacy of the digital intervention on reducing vaping behaviors among teens and young adults.

Conditions

Nicotine Vaping

Nicotine Use Disorder

Study ID

NCT05994209

Start date

Jun 4, 2025

Status verified date

Apr, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 15 - 25

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • US Resident
  • English Speaking
  • Have daily access to a smartphone
  • Current vaping product user (P30D)
  • Identified as socially networking about a desire to quit vaping and/or experiencing negative health outcomes due to vaping
  • Vaping product user only (i.e., not using vaping as a means to support combustible smoking cessation)

Study Design

Enrollment

189 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: Control Group

Nationwide resource referral and intervention waitlist

experimental: Experimental Group A: Mobile App Intervention

quitSTART Mobile Application Adapted for Vaping Cessation Among Young Adults

experimental: Experimental Group B: Mobile App Intervention with Embedded Chatbot Feature

quitSTART Mobile Application Adapted for Vaping Cessation Among Young Adults Including Embedded Chatbot Feature

Interventions

quitSTART Mobile Application

Mobile application with educational content, motivational messages, self-monitoring, and tips for managing cravings to support vaping cessation among young adults.

Chatbot Feature in quitSTART Mobile Application

In-App chatbot feature emedded into quitSTART mobile application to motivate vaping cessation and support app navigation.

Primary outcome measure

  • Vaping cessation [ Time Frame: Baseline, 6 weeks, 3 months ]

Central Contacts and Locations

Central contacts

Locations

Washington University in St. Louis, School of Medicine

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Principal Investigator:

Patricia Cavazos-Rehg, PhD

More Information

Sponsor

Washington University School of Medicine

Last update posted

Apr 13, 2026

Last verified

Apr, 2026

Keywords

  • vaping
  • mobile app intervention
  • youth
  • young adults
  • chatbot
  • nicotine
  • social media

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Washington University School of Medicine on 2026-04-13.