Recruiting

Observational Study

Sponsor:

Dartmouth-Hitchcock Medical Center

Code:

NCT06001736

Conditions

Stroke, Ischemic

Stroke Hemorrhagic

Spastic Hemiparesis

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Contralateral C7 root transfer for the treatment of spastic hemiparesis.

Study Details

Brief summary:

The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.

Conditions

Stroke, Ischemic

Stroke Hemorrhagic

Spastic Hemiparesis

Study ID

NCT06001736

Start date

Mar 13, 2022

Status verified date

Feb, 2026

Completion date

Mar 1, 2027

Anticipated

Primary completion date

Mar 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.
  • baseline Fugl-Meyer score below 33

Exclusion Criteria:

  • pregnancy

Study Design

Enrollment

95 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Contralateral C7 root transfer for the treatment of spastic hemiparesis.

The C7 nerve root transfer will occur to the patients on this arm.

Interventions

Contralateral C7 root transfer for the treatment of spastic hemiparesis.

Performing surgery to transfer the C7 nerve to treat stroke patients experiencing spastic hemiparesis.

Primary outcome measure

  • Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale. [ Time Frame: 12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery. ]

Central Contacts and Locations

Central contacts

Lauren Sinks

(603) 653-9021Lauren.J.Sinks@hitchcock.org

Locations

Dartmouth-Health

Recruiting

Lebanon, New Hampshire, United States, 03677

Contacts

Lauren Sinks, MPH

603-653-9021Lauren.J.Sinks@Hitchcock.org

Principal Investigator:

Jennifer Hong, MD

More Information

Sponsor

Dartmouth-Hitchcock Medical Center

Last update posted

Feb 27, 2026

Last verified

Feb, 2026

Keywords

  • Ischemic stroke
  • Hemorrhagic stroke
  • Spastic hemiparesis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dartmouth-Hitchcock Medical Center on 2026-02-27.