Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT06030674

Conditions

Healthy

Eligibility Criteria

Sex: All

Age: 21 - 50

Healthy Volunteers: Accepted

Interventions

Secondhand cannabis emissions/smoke exposure

Study Details

Brief summary:

This is an unblinded pilot study of an environmental exposure to secondhand cannabis smoke in one group of healthy nonsmokers.

Conditions

Healthy

Study ID

NCT06030674

Start date

Sep 1, 2023

Status verified date

Jun, 2026

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

\-

Adult nonsmokers, aged 21-50, who:

  • Are healthy on the basis of medical history
  • Have systolic blood pressure <150
  • Have diastolic blood pressure <100
  • Have BMI between 18.1 and 34.9
  • Able to perform moderate exercise,
  • Are not exposed to tobacco or cannabis SHS in their daily lives. (Nonsmoking status and low SHS exposure are determined by self-report on the screening questionnaire, salivary cotinine < 10 ng/ml and THC < 50 ng/m and exhaled CO2 below 4 ppm)

Exclusion Criteria:

  • Current use of cannabis products, including CBD and edible THC products
  • Regular exposure to secondhand tobacco or cannabis smoke
  • Positive SARS-CoV-2 antibody test
  • Age 18 < or > 50
  • Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.
  • Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications
  • Systolic blood pressure > 150
  • Diastolic blood pressure > 100
  • Pregnancy or breastfeeding (by urine hCG and/or history)
  • Alcohol or illicit drug dependence within the past 5 years
  • BMI > 35 and < 18
  • Current illicit drug use (by history or urine test)
  • More than 1 pack year smoking history
  • Ever a daily marijuana smoker
  • Smoked anything within the last 2 months
  • Occupational exposure to smoke, dusts OR fumes
  • Concurrent participation in another clinical trial
  • Unable to communicate in English
  • No social security number

Study Design

Enrollment

200 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Exposure to secondhand cannabis smoke in public places

The research staff and participants will travel together to a public location by either ride share vehicles, taxis or public transit. The study will arrange and pay for the transit. Staff and participants will be exposed to ambient air in public places where cannabis products are being consumed by smoking, vaporizing or dabbing. Participants will remain in the company of the laboratory staff throughout the exposure. The exposures will last 0.5-4 hours, depending on the nature and duration of the event. Staff and participants will travel together back to the laboratory for the post-exposure study measures.

Interventions

Secondhand cannabis emissions/smoke exposure

This is an environmental exposure performed in public places where people are consuming cannabis.

Primary outcome measure

  • Change in the concentration of urinary cannabinoid metabolites in health nonsmokers exposed to cannabis smoke and emissions [ Time Frame: Baseline (before exposure) and the morning after exposure, up to 22 hours. ]

Central Contacts and Locations

Central contacts

Suzaynn F Schick, Phd

4155143535suzaynn.schick@ucsf.edu

Abel Huang, BS

415-514-9011abel.huang@ucsf.edu

Locations

Zuckerberg San Francisco General Hospital

Recruiting

San Francisco, California, United States, 94110

Contacts

Abel Huang

Abel.Huang@ucsf.edu

Principal Investigator:

Suzyann Schick, PhD

More Information

Sponsor

University of California, San Francisco

Last update posted

Jun 16, 2026

Last verified

Jun, 2026

Keywords

  • Nonsmokers
  • Secondhand cannabis smoke
  • Environmental cannabis
  • Exposure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-06-16.