Recruiting

AM vs. PM Exercise

Sponsor:

Michigan State University

Code:

NCT06042439

Conditions

Hypertension

Eligibility Criteria

Sex: Female

Age: 55 - 70+

Healthy Volunteers: Not accepted

Interventions

6 weeks of exercise training (Pre-training)

6 weeks of exercise training (Post-training)

Study Details

Brief summary:

The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.

Conditions

Hypertension

Study ID

NCT06042439

Start date

Jun 11, 2024

Status verified date

Sep, 2025

Completion date

Jul 1, 2027

Anticipated

Primary completion date

Jul 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 55 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg
  • 55-80 years old
  • Post-menopausal female
  • Able to walk without assistance

Exclusion Criteria:

  • Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week
  • Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension
  • Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months
  • Cancer within last 5 years
  • Body mass index >39 kg/m2
  • Current smoking or vape
  • Evening shift work
  • uncontrolled thyroid disorder
  • 2 or more falls in the last year
  • Anemia within 3 months of enrollment
  • Parkinson's disease
  • Dementia
  • Unstable angina
  • Acute pulmonary embolus or infarction
  • Acute myocarditis or pericarditis
  • Acute aortic dissection

Study Design

Enrollment

79 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Morning (AM)

Exercise starting before 10:01 AM

experimental: Evening (PM)

Exercise starting after 3:59 PM

Interventions

6 weeks of exercise training (Pre-training)

handgrip and treadmill walking 4 days per week

6 weeks of exercise training (Post-training)

handgrip and treadmill walking 4 days per week

Primary outcome measure

  • Nocturnal systolic blood pressure (BP) [ Time Frame: 6 weeks ]

Central Contacts and Locations

Central contacts

Jill Slade, PhD

5178843351jslade@msu.edu

Katharine Currie, PhD

517-432-4073curriek4@msu.edu

Locations

Michigan State University

Recruiting

East Lansing, Michigan, United States, 48824

Contacts

Jill Slade, PhD

517-884-3351jslade@msu.edu

Katharine Currie, PhD

517-432-4073curriek4@msu.edu

More Information

Sponsor

Michigan State University

Last update posted

Sep 25, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Michigan State University on 2025-09-25.