Recruiting

Observational Study

Sponsor:

University of Rochester

Code:

NCT06047717

Conditions

Stroke, Ischemic

Quadrantanopia

Hemianopsia, Homonymous

Hemianopia, Homonymous

Hemianopia

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Interventions

Virtual Reality Driving Task

Study Details

Brief summary:

The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).

Conditions

Stroke, Ischemic

Quadrantanopia

Hemianopsia, Homonymous

Hemianopia, Homonymous

Hemianopia

Study ID

NCT06047717

Start date

Nov 28, 2023

Status verified date

Aug, 2026

Completion date

Oct, 2028

Anticipated

Primary completion date

Oct, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Cortically Blind Group:

Inclusion Criteria:

  • Residents of the United States or Canada
  • Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
  • Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.
  • Willing, able, and competent to provide their own informed consent
  • Cognitively able, responsible to understand written and oral instructions in English
  • Emmetropic or else wear corrective contact lenses inside the virtual reality headset

Exclusion Criteria:

  • Those who have never driven or earned a drivers' license
  • Past or present ocular disease interfering with visual acuity
  • Best corrected visual acuity (BCVA) worse than 20/40 in either eye
  • Sustained damage to the dorsal lateral geniculate nucleus
  • Presence of diffuse, whole-brain degenerative processes
  • Presence of brain damage deemed by study staff to potentially interfere with outcome measures
  • History of traumatic brain injury
  • Documented history of drug/alcohol abuse
  • Diagnosis of cognitive or seizure disorders
  • Diagnosis of one-sided attentional neglect

Control Group:

Inclusion Criteria:

  • Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above
  • Competent and responsible, as determined by the Principal Investigator
  • Willing, able, and competent to provide their own informed consent
  • Normal cognitive abilities, be able to understand written and oral instructions in English
  • Emmetropic or else wear corrective contact lenses inside the virtual reality headset

Exclusion Criteria:

  • Subjects who have never driven or earned a drivers' license
  • BCVA worse than 20/40 in either eye
  • Presence of vision loss from ocular diseases or disorders
  • Presence of a visual field defect
  • Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly
  • Subjects with a history of neurological disorders
  • Subjects with a history of TBI
  • Persons who lack the competence or are otherwise unable to perform the visual testing as directed.

Study Design

Enrollment

40 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Virtual Reality (VR) Driving Task: Cortically Blind Cohort

Persons who have sustained cortical blindness will perform a driving task in VR, in which they must steer through a series of parameterized turns while maintaining their virtual vehicle centered between the two red lines delineating the "road" edge.

experimental: Virtual Reality (VR) Driving Task: Healthy Control Cohort

Healthy controls with no vision loss will perform a driving task in VR, in which they must steer through a series of parameterized turns while maintaining their virtual vehicle centered between the two red lines delineating the "road" edge.

Interventions

Virtual Reality Driving Task

Participants will steer a virtual car with the goal of staying in the center of a single-lane roadway while traveling at a constant speed of 26.6 m/s (approximately 60 miles/hr). The roadway alternates between a series of straights and turns of different radii to both the left and the right. This allows for careful control of task difficulty, and for the repeated presentation of specific conditions across multiple "trials" (i.e. turns in the road) in a randomized order. In addition, the density of the visual texture elements in the virtual environment that provide optic flow (OF) signal is also varied. The low-density OF condition has no road texture or foliage, and only the solid road edges on a flat-black ground plane. The medium-density OF condition has sparse textural elements distributed on the ground plane, and the high-density OF condition has high density road texture and a canopy of road-side trees that provide texture extending far above the horizon.

Primary outcome measure

  • Virtual Reality (VR) Lane Deviation / Offset [ Time Frame: Day 0 ]

Central Contacts and Locations

Central contacts

Evan Burr

585-275-5234Evan_Burr@URMC.Rochester.edu

Locations

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Evan Burr

585-275-5234Evan_Burr@urmc.rochester.edu

Principal Investigator:

Krystel Huxlin, PhD

More Information

Sponsor

University of Rochester

Last update posted

Aug 25, 2026

Last verified

Aug, 2026

Keywords

  • Occipital stroke
  • Vision loss after stroke
  • Vision recovery
  • Vision restoration
  • Partial vision loss
  • Homonymous quadrantanopsia
  • Homonymous quadrantanopia
  • stroke

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Rochester on 2026-08-25.