Recruiting

Percussive Massage

Sponsor:

Brigham Young University

Code:

NCT06053229

Conditions

Massage Therapy

Muscular Atrophy

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Interventions

percussive massage

Leg Immobilization

Study Details

Brief summary:

The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested:

Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry.

Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow.

Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.

Conditions

Massage Therapy

Muscular Atrophy

Study ID

NCT06053229

Start date

Mar 1, 2023

Status verified date

Aug, 2024

Completion date

Jul 31, 2025

Anticipated

Primary completion date

Dec 31, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-50 years old (women are pre-menopausal). We will exclude individuals over the age of 50 because the adaptive capability of skeletal muscle fundamentally changes with older age, and the risk from disuse increases. The findings of this study will help determine the risk benefit relationship of conducting a similar study in older individuals.
  • Stable levels of physical activity for at least 6 months
  • No history of lower extremity injury that would preclude their ability to perform knee extension exercise

Exclusion Criteria:

  • Cigarette or marijuana smoker
  • Pregnant or planning to become pregnant within next month
  • Cardiovascular, metabolic disease or cognitive disease (e.g. Alzheimer's or mild cognitive impairment)
  • Taking prescribed medications (e.g. blood pressure medication) or anti-depressants
  • Habitual use of any type of massage or vibration on their thigh
  • Note that subjects who are mentally unable to understand the consenting process and provide informed consent will not be included in this study.

Study Design

Enrollment

36 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Massage

Subjects will receive a daily 30 minute percussive massage treatment on the knee extensor muscles twice per day during the 10 day immobilization period

sham comparator: Control

This group will lie on the bed for a total of 30 minutes, but receive no massage

Interventions

percussive massage

30 minutes of percussive massage will be administered twice per day during the 10 day immobilization period using a percussive massage device

Leg Immobilization

All subjects will have their left leg immobilized using an immobilization brace for 10 days

Primary outcome measure

  • knee extensor muscle strength [ Time Frame: Immediately before the onset of leg immobilization and after 10 days of leg immobilization ]
  • Vastus lateralis cross-sectional area [ Time Frame: Immediately before the onset of leg immobilization and after 10 days of leg immobilization ]
  • Skeletal muscle mitochondrial function [ Time Frame: Immediately before the onset of leg immobilization and after 10 days of leg immobilization ]

Central Contacts and Locations

Central contacts

Robert D Hyldahl, PhD

8014221237robhyldahl@byu.edu

Ty Hopkins, PhD

8014221573

Locations

Brigham Young University

Recruiting

Provo, Utah, United States, 84602

Contacts

Robert D Hyldahl, PhD

801-422-1237robhyldahl@byu.edu

Ty Hopkins, PhD

8014221573jthops@me.com

More Information

Sponsor

Brigham Young University

Last update posted

Aug 13, 2024

Last verified

Aug, 2024

Keywords

  • Massage
  • immobilization

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Brigham Young University on 2024-08-13.