Recruiting

Exercise & Nutrition

Sponsor:

University of Toronto

Code:

NCT06054620

Conditions

Interventional

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Interventions

Collagen and Vitamin C

Carbohydrate Placebo

Study Details

Brief summary:

The primary objective of this study will be to determine the influence of a presleep vitamin C-enriched, collagen-modelled supplement (CVC) on the metabolic fate of dietary glycine using a \[2H5\]glycine tracer within the intramuscular connective tissue at rest and after a bout of resistance exercise. Other outcomes will be related to regulation collagen remodelling in skeletal muscle.

Conditions

Interventional

Study ID

NCT06054620

Start date

Sep 15, 2023

Status verified date

Nov, 2023

Completion date

Aug 1, 2025

Anticipated

Primary completion date

Sep 1, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy, recreationally active, male and female participants.
  • Healthy will be defined as someone who does not have a health condition that would compromise their ability to safely participate in the strenuous physical activity involved in our study as screened for by the Get Active Questionnaire.
  • Willing to abstain from resistance exercise for 2 weeks prior to the first metabolic trial and for the duration of the study.
  • Participants must be able to abstain from lower-body resistance and/or plyometric exercise for at least 2 weeks prior to the first metabolic trial.
  • Participants will be aged 18-35 years old.
  • Participants must be normal to overweight (e.g., BMI 18.5-30).
  • Participants are willing to abide by the compliance rules of this study (e.g., abstain from physical activity and alcohol 48h prior to each trial).
  • Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).

Exclusion Criteria:

  • Inability to adhere to any of the compliance rules judged by principal investigator or medical doctor.
  • Self-reported regular tobacco use.
  • Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.).
  • Regular use of anti-inflammatory drugs (e.g., ibuprofen).
  • Self-reported regularly sleeping less than an average of 7 hours over 3 days (minimum recommended daily amount).
  • Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.
  • Use of birth control and discontinued use in the last 3-months (female only).

Study Design

Enrollment

12 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Collagen and Vitamin C

placebo comparator: Carbohydrate Placebo

Interventions

Collagen and Vitamin C

Collagen-modelled crystalline amino acids (30g total, 8g glycine) and vitamin C (500 mg).

Carbohydrate Placebo

Iso-caloric Placebo (30g maltodextrin).

Primary outcome measure

  • Enrichment of Muscle Collagen [ Time Frame: 9 hours ]

Central Contacts and Locations

Central contacts

Daniel R Moore, PhD

416-946-4088dr.moore@mail.utoronto

Paul L Babits, BKin

647-609-4710paul.babits@mail.utoronto.ca

Locations

Goldring Centre for High Performance Sport at the University of Toronto

Recruiting

Toronto, Ontario, Canada, M5S 2C9

Contacts

Dan R Moore, PhD

647-946-4088dr.moore@mail.utoronto.ca

Paul L Babits, BKin

paul.babits@mail.utoronto.ca

More Information

Sponsor

University of Toronto

Last update posted

Nov 13, 2023

Last verified

Nov, 2023

Keywords

  • Collagen
  • Vitamin C
  • Carbohydrate placebo

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Toronto on 2023-11-13.