Recruiting

Phase 1

TNM005A Trial to Evaluate the Safety, Pharmacokinetics and Pharmacodynamic Profile of TNM005 in Healthy Adult Subjectsy

Sponsor:

Zhuhai Trinomab Pharmaceutical Co., Ltd.

Code:

NCT06068608

Conditions

Varicella

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

TNM005

Placebo

VariZIG

Study Details

Brief summary:

The purpose of this clinical trial is to evaluate the safety and tolerability of TNM005 following a single dose by intramuscular (IM) administration in healthy adult subjects The main questions it aims to answer are:1. safety profile；2. PK properties 3. PD properties

Conditions

Varicella

Study ID

NCT06068608

Start date

Sep 12, 2023

Status verified date

Sep, 2023

Completion date

Dec 31, 2024

Anticipated

Primary completion date

Dec 31, 2024

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

1) Signed and dated written informed consent;
2) Are willing and able to comply with scheduled visits, blood sampling, laboratory tests, and other study procedures;
3) Healthy males or females, 18-55 years of age (both inclusive);
4) Body mass index (BMI) within 18.5-31.0 kg/m2 (both inclusive) and body weight ≥50.0 kg for males and ≥45.0 kg for females;
5) Have no clinically significant abnormality on physical examination, vital signs, 12-lead ECG, and clinical laboratory tests as determined by the Investigator;
6) Females must be either surgically sterile or under post-menopausal status at Screening or agree to use a highly effective method of contraception from screening until 120 days after IMP dosing. In addition, males who are sexually active and partners of women of childbearing potential must agree to use effective contraception from screening until 120 days after drug administration.

Exclusion Criteria:

1) History or evidence of any other acute or chronic disease that, in the opinion of the Investigator, may interfere with the evaluation of the safety or immunogenicity of the drug or compromise the safety of the subject;
2) History of surgery (except minor outpatient surgery) within three months prior to screening or planned surgery during the study;
3) History of receiving monoclonal antibody, immunoglobulin, or blood products within six months prior to dosing;
4) Receipt of systemic immunosuppressive medications;
5) Exposure to any live attenuated vaccine within four weeks prior to drug administration;
6) History of receiving vaccine(s) against zoster;
7) Use of any other drug, including over-the-counter medications, and herbs, within 14 days prior to the drug administration or five half-lives of the drug, whichever is longer, except for contraceptive medication in women of childbearing potential (WOCBP), or concomitant medications that are considered necessary for the subject's welfare and unlikely to interfere with the study;
8) Donated blood >400 mL or significant blood loss equivalent to 400 mL within one month before Screening; or plasma donation within 14 days before Screening; or any plan of blood or blood product donation during the study;
9) Positive test at a screening of any of the following: hepatitis B surface antigen (HBsAg), hepatitis C (HCV) antibody, or human immunodeficiency virus (HIV) antigen/antibody;
10) Known or suspected history of drug abuse within the past five years or with a positive urine drug test at Screening or on Day -1;
11) History of significant alcohol abuse within six months prior to screening or any indication of regular use of more than 14 units of alcohol per week or taking a product containing alcohol two days prior to dosing, or having a positive alcohol breath test on Day -1;
12) Use of ≥five cigarettes or equivalent nicotine-containing product per day on average over three months prior to Screening; or unwilling to refrain from nicotine products during study participation;
13) History of allergic or anaphylactic reaction to a therapeutic or diagnostic monoclonal antibody or IgG-fusion protein;
14) History of allergic or anaphylactic reaction to blood products (only for VARIZIG cohort);
15) IgA deficient subjects at risk for hypersensitivity reaction (only for VARIZIG cohort);
16) Subjects at high risk for thrombotic events, including those with a history of venous or arterial thrombosis, atherosclerosis, or multiple cardiovascular risk factors (only for VARIZIG cohort);
17) Participation in any other clinical studies with chemical or biological drugs or devices within four weeks or five times the half-life of the specific drug/biologics (whichever is longer) before drug administration;
18) Nursing mothers or pregnant women;
19) Subjects considered unsuitable for participating in the study in the opinion of the Investigator.

Study Design

Enrollment

48 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: TNM005 dose level 1/placebo

TNM005 on dose level 1 /placebo

experimental: TNM005 dose level 2/placebo

TNM005 on different dose level 2 /placebo

experimental: TNM005 level 3/placebo

TNM005 on dose level 3 /placebo

experimental: TNM005 dose level 4/placebo

TNM005 on dose level 4 /placebo

experimental: TNM005 dose level 5/placebo

TNM005 on dose level 5 /placebo

active comparator: VARIZIG

VARIZIG 625 IU

Interventions

TNM005

single,intramuscular injection

Placebo

single,intramuscular injection

VariZIG

a single dose of VARIZIG 625 IU,intramuscular injection

Primary outcome measure

Incidence of AEs [ Time Frame: Up to 120 days post dosing ]
Number of participants Physical examinations abnormalities [ Time Frame: Up to 120 days post dosing ]
Number of participants with abnormalities of vital signs [ Time Frame: Up to 120 days post dosing ]
Number of participants with abnormalities of 12-lead electrocardiogram (ECG) parameters [ Time Frame: Up to 120 days post dosing ]
Number of participants with abnormalities of clinical laboratory tests [ Time Frame: Up to 120 days post dosing ]

Central Contacts and Locations

Central contacts

Ying Wang

+86 0756 7263999 emma.wang@trinomab.com

Miaoyan Chen

+86 0756 7263999 chenmiaoyan@trinomab.com

Locations

ICON, plc

Recruiting

Salt Lake City, Utah, United States, 84124

Contacts

Ahad Sabet, MD

801-269-8200 Ahad.Sabet@iconplc.com

More Information

Sponsor

Zhuhai Trinomab Pharmaceutical Co., Ltd.

Last update posted

Jul 11, 2024

Last verified

Sep, 2023

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Zhuhai Trinomab Pharmaceutical Co., Ltd. on 2024-07-11.