Recruiting

Observational Study

Sponsor:

National Alliance for Sickle Cell Centers

Code:

NCT06071377

Conditions

Sickle Cell Trait

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Biologic Specimen Collection

Study Details

Brief summary:

The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.

Conditions

Sickle Cell Trait

Study ID

NCT06071377

Start date

Apr 1, 2023

Status verified date

Nov, 2025

Completion date

Feb, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Are willing to voluntarily participate and sign the study consent
2. Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status
3. Adults ages 18 and older

Exclusion Criteria:

1. Unwilling to sign consent
2. Known end-stage renal disease or dialysis
3. Known SCD (including sickle cell-beta thalassemia)
4. People who do not have SCT

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Individuals with sickle cell trait

Interventions

Biologic Specimen Collection

Participants will have blood and urine collected at Baseline

Primary outcome measure

  • Hemoglobin variant quantification [ Time Frame: Through study completion, an average of 2 years ]

Central Contacts and Locations

Central contacts

Julie Kanter, MD

(202) 596-1548jkanter@sicklecellcenters.org

Locations

University of Alabama

Recruiting

Birmingham, Alabama, United States, 35294

Contacts

Marteesa William Oliver

marteesawilliams@uabmc.edu

Principal Investigator:

Julie Kanter

Loma Linda University Health Care

Recruiting

Loma Linda, California, United States, 92354

Contacts

Monica Pizana

mpizana@llu.edu

Principal Investigator:

Akshat Jain

Nemours Children's Hospital

Recruiting

Wilmington, Delaware, United States, 19803

Contacts

Nicole Wittmeyer

Nicole.Wittmeyer@nemours.org

Principal Investigator:

Robin Miller, MD

Indiana University

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Claire Kendrick

cjkendri@iu.edu

Principal Investigator:

Andrew O'Brien

Functional Fluidics

Recruiting

Detroit, Michigan, United States, 48202

Contacts

Jennell White, PhD

jennell.white@functionalfluidics.com

Ifeoma Iwuagwu

ifeoma.iwuagwu@functionalfluidics.com

Principal Investigator:

Patrick Hines, MD

University of North Carolina

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

David Wichlan

david_wichlan@med.unc.edu

Principal Investigator:

Patrick Ellison

Duke University

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Morgan Low

morgan.low@duke.edu

Principal Investigator:

JJ Strouse, MD

East Carolina University

Recruiting

Greenville, North Carolina, United States, 27834

Contacts

Sean Segre

segres24@ecu.edu

Principal Investigator:

Beng Fuh

Nationwide Children's Hospital

Recruiting

Columbus, Ohio, United States, 43205

Contacts

Tiffany Rosetti

Tiffany.Rossetti@nationwidechildrens.org

Principal Investigator:

Anthony Villella, MD

UT Health Houston

Recruiting

Houston, Texas, United States, 77030

Contacts

Amanda Gregg

amanda.gregg@uth.tmc.edu

Principal Investigator:

Idowu Modupe, MD

More Information

Sponsor

National Alliance for Sickle Cell Centers

Last update posted

Nov 6, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by National Alliance for Sickle Cell Centers on 2025-11-06.