Recruiting

MY-RIDE

Sponsor:

The University of Texas Health Science Center, Houston

Code:

NCT06074354

Conditions

HIV Infections

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Not accepted

Interventions

Attention-control group

MY-RIDE group

Study Details

Brief summary:

The purpose of this study is to determine whether Motivating Youth to Reduce Infections, Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention strategies and to evaluate MY-RIDE effects on willingness to take Pre-Exposure Prophylaxis (PrEP), stress, substance use urge, and use of mental health and substance use services when compared to attention control youth

Conditions

HIV Infections

Study ID

NCT06074354

Start date

Nov 11, 2024

Status verified date

May, 2026

Completion date

Aug 23, 2027

Anticipated

Primary completion date

Aug 23, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • have engaged in substance use (alcohol or illicit drugs)
  • speak English
  • are experiencing homelessness
  • engaged in sexual activity in the last 6 months or plan to in the next month
  • are not planning to move out of the metro area during the 15-month study period.

Exclusion Criteria:

  • Youth Experiencing Homelessness (YEH) who have low literacy based on the Rapid Estimate of Adult Literacy in Medicine-Short Form (scores < 4)

Study Design

Enrollment

450 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: MY-RIDE group

active comparator: Attention-control group

Interventions

Attention-control group

Participants will receive a one-hour general health promotion session from a nurse and be issued a phone that will deploy the EMA on the same schedule as the intervention arm. They will also receive usual care from the clinics, drop-in center, and shelter recruitment sites. Usual care includes accessing social workers and case managers for immediate housing, food, and clothing needs and assistance in navigating the local Continuum of Care system to access social services.

MY-RIDE group

MY-RIDE has three main components: 1) One nurse-led face-to-face session; 2) three months of Ecological Momentary Assessments (EMA) with personalized messaging delivered by phone in real-time in response to one's current risk; and 3) access to on-demand healthcare/PrEP navigation and referrals.

Primary outcome measure

  • Change in substance use [ Time Frame: baseline, end of intervention (3 months after baseline), 3 months after intervention, 6 months after intervention, and 12 months after intervention ]

Central Contacts and Locations

Central contacts

Diane M Santa Maria, DrPH, MSN, RN, PHNA-BC, FSAHM

713-500-2002Diane.M.SantaMaria@uth.tmc.edu

Jennifer Jones

713-500-9928Jennifer.D.Torres@uth.tmc.edu

Locations

The University of Texas Health Science Center at Houston

Recruiting

Houston, Texas, United States, 77030

Contacts

Diane M Santa Maria, DrPH, MSN, RN, PHNA-BC, FSAHM

713-500-2002Diane.M.SantaMaria@uth.tmc.edu

Jennifer Jones

713-500-9928Jennifer.D.Torres@uth.tmc.edu

More Information

Sponsor

The University of Texas Health Science Center, Houston

Last update posted

May 13, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center, Houston on 2026-05-13.