Recruiting

Yoga

Sponsor:

UCLA

Code:

NCT06091527

Conditions

Depression Mild

Depression Moderate

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Yoga practice

Education

Study Details

Brief summary:

The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate major depression at the Zuckerberg San Francisco General Hospital. Researchers will compare the yoga interventions to an education control intervention on holistic healthcare.

Conditions

Depression Mild

Depression Moderate

Study ID

NCT06091527

Start date

Oct 25, 2024

Status verified date

Nov, 2025

Completion date

Jun, 2026

Anticipated

Primary completion date

Jun, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion criteria:

  • 18 years of age or older
  • Able to give voluntary, informed consent
  • English-speaking
  • Diagnosis of clinical depression

Exclusion criteria:

  • Current use of antidepressant medication
  • Current engagement in psychotherapy
  • Current pregnancy
  • Significant medical issues interfering with yoga practice

Study Design

Enrollment

180 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Yoga practice

Yoga practice groups

active comparator: Education

Education module group

Interventions

Yoga practice

90-minute group yoga classes twice weekly for 12 weeks.

Education

90-minute group education classes twice weekly for 12 weeks to learn holistic healthcare modules.

Primary outcome measure

  • Change in Beck Depression Inventory-II score [ Time Frame: Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks and 12 weeks ]

Central Contacts and Locations

Central contacts

Sudha Prathikanti, MD

415-516-3867sudha.prathikanti@ucsf.edu

Locations

Zuckerberg San Francisco General Hospital

Recruiting

San Francisco, California, United States, 94110

Contacts

Sudha Prathikanti, MD

415-516-3867sudha.prathikanti@gmail.com

Principal Investigator:

Sudha Prathikanti, MD

More Information

Sponsor

University of California, San Francisco

Last update posted

Nov 6, 2025

Last verified

Nov, 2025

Keywords

  • yoga
  • ayurveda
  • depression

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2025-11-06.