Recruiting

Anti-MRSA Antibiotics

Sponsor:

Methodist Health System

Code:

NCT06096012

Conditions

Osteomyelitis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Anti-MRSA therapy

Study Details

Brief summary:

Osteomyelitis is described as infection and inflammation of the long bone or bone marrow, often due to an open wound, operation, or invasive trauma.1 It is invasive and involves hematogenous seeding or contiguous spread of the infectious organism

Conditions

Osteomyelitis

Study ID

NCT06096012

Start date

Jun 23, 2023

Status verified date

Aug, 2023

Completion date

Jun 23, 2024

Anticipated

Primary completion date

Jun 23, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • • Admission to any MHS hospital between April 1, 2017 and April 1, 2023

  • > 18 years of age
  • Documented osteomyelitis location of the lower limb via ICD-10 code
  • Documented imaging of lower limb osteomyelitis during index admission
  • Planned intravenous (IV) antibiotics for at least 4 weeks

Exclusion Criteria:

  • • IV antibiotics for less than 24 hours inpatient

  • Planned surgical intervention documented at admission
  • Patients receiving monotherapy with an anti-MRSA agent
  • Positive MRSA culture during index admission
  • Current outpatient antibiotic use on index admission
  • Repeated hospital admission during study period

Study Design

Enrollment

365 participants

Anticipated

Interventions and Outcome Measures

Interventions

Anti-MRSA therapy

chart review to determine the clinical outcomes of patients with osteomyelitis who were placed on definitive anti-MRSA treatment, despite no identified MRSA cultures.

Primary outcome measure

  • Comparison of treatment [ Time Frame: 180 Days ]

Central Contacts and Locations

Central contacts

Bethany Brauer, MPH

214-947-4681MHSIRB@mhd.com

Colette Ngo Ndjom, MS

214-947-4681mhsirb@mhd.com

Locations

Methodist Dallas Medical Center

Recruiting

Dallas, Texas, United States, 75203

Contacts

Colette Ngo Ndjom, MS

214-947-4681mhsirb@mhd.com

Bethany Brauer, MPH

217-947-4681mhsirb@mhd.com

More Information

Sponsor

Methodist Health System

Last update posted

Oct 23, 2023

Last verified

Aug, 2023

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Methodist Health System on 2023-10-23.