Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT06096532

Conditions

Healthy

Aging

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

75 gm oral glucose load

Study Details

Brief summary:

The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults.

The main question\[s\] it aims to answer are:

  • Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adults
  • What molecular and systemic signatures related to adipose tissue blood flow are altered between these two groups.

Participants will undergo measurements of adipose tissue blood flow using the xenon washout technique, undergo 2 abdominal subcutaneous adipose tissue biopsies, and drink a sugary drink.

Conditions

Healthy

Aging

Study ID

NCT06096532

Start date

Feb 15, 2024

Status verified date

Jan, 2026

Completion date

Dec 30, 2028

Anticipated

Primary completion date

Dec 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion criteria

  • Within the ages of 18-35 years or 65-80 years at time of study visit
  • BMI between 20-25.0 kg/m2.

Exclusion criteria:

  • Presence of diagnosed cardiometabolic diseases (e.g., Type 2 diabetes, hypertension, Heart Failure)
  • Taking prescription anticoagulants
  • Taking prescriptions or supplements that effect adipose tissue metabolism (i.e., statins, Thiazolidinediones, niacin, atypical antipsychotics, or fish oil)
  • Pregnant or nursing
  • Inability to provide written informed consent
  • Smokers

Study Design

Enrollment

24 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Older Adults

active comparator: Younger Adults

Interventions

75 gm oral glucose load

Consumption of 75 gm oral glucose load in order to test nutrient responsiveness

Primary outcome measure

  • Adipose tissue blood flow [ Time Frame: Baseline, pre-intervention fasting and immediately following 75 gm oral glucose load ]

Central Contacts and Locations

Locations

Mayo Clinic Minnesota

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Kelli A Lytle, PhD

507-255-1488lytle.kelli@mayo.edu

More Information

Sponsor

Mayo Clinic

Last update posted

May 1, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-05-01.