Recruiting

Exercise Regimen

Sponsor:

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Code:

NCT06115486

Conditions

Breast Cancer

Breast Carcinoma in Situ

Breast Cancer Female

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Interventions

Control Arm ACSM Guidelines

Experimental Arm 6-12-25 repetitions per set

Study Details

Brief summary:

The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.

Conditions

Breast Cancer

Breast Carcinoma in Situ

Breast Cancer Female

Study ID

NCT06115486

Start date

Jan 9, 2024

Status verified date

Feb, 2026

Completion date

Jan, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Age 20-89 years

  • Women with a biopsy proven diagnosis of ductal carcinoma in situ or invasive carcinoma of the breast
  • Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.

Exclusion Criteria:

  • Any current treatment with cytotoxic chemotherapy for breast cancer
  • Inability to safely engage in group sessions of resistance training as deemed by study PI
  • Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Control Arm / ACSM Guidelines

The control group will follow resistance training guidelines from the American College of Sports Medicine (ACSM) with the goal of promoting hypertrophy

experimental: Experimental Arm / EOC Guidelines

The experimental group will use a regimen that is often used by strength and conditioning coaches to maximize hypertrophy, and is part of the standard regimens at the Exercise Oncology Center (EOC)

Interventions

Control Arm ACSM Guidelines

The control group will follow resistance training guidelines from the American College of Sports Medicine. Eight to ten multi-joint exercises will be performed to stress the major muscle groups.

Experimental Arm 6-12-25 repetitions per set

The exercise regimens will employ a mixture of compound exercises utilizing both open and closed kinetic chain movements (CKC), focusing on exercises with the goal of increasing skeletal muscle mass and body composition. The regimen will incorporate 6, then 12, then 25 repetitions in sequence per set per muscle group with minimal amounts of rest between.

Primary outcome measure

  • Determine changes in muscle and fat mass during and after each exercise regimen [ Time Frame: The exercise program will last for 8 weeks and continuously monitored by the PI and clinical team. ]

Central Contacts and Locations

Central contacts

Clinical Trials Contact

4123306151clinicaltrials@ahn.org

Locations

Allegheny General Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15212

Contacts

Clinical Trials Contact

clinicaltrials@ahn.org

More Information

Sponsor

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Last update posted

Feb 4, 2026

Last verified

Feb, 2026

Keywords

  • Cancer
  • Carcinoma in Situ
  • Hypertrophy
  • Exercise

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) on 2026-02-04.