Recruiting
Phase 2

Cannabigerol

Sponsor:

University of Arkansas, Fayetteville

Code:

NCT06115603

Conditions

Attention-Deficit/Hyperactivity Disorder

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

Cannabigerol

Placebo

Study Details

Brief summary:

The goal of this clinical trial is to evaluate the effects of Cannabigerol (CBG) on indicators of Attention-Deficit/Hyperactivity Disorder (ADHD) in a sample of participants indicating/reporting symptoms associated with ADHD. The main question it aims to answer is: Does CBG reduce ADHD-related indicators relative to placebo? Participants will administer an acute dose of placebo or 80mg CBG and complete outcome measures at 45 minutes and 75 minutes. Daily surveys to monitor safety will be administered for one week following administration.

Conditions

Attention-Deficit/Hyperactivity Disorder

Study ID

NCT06115603

Start date

Dec 14, 2024

Status verified date

May, 2026

Completion date

Jul, 2026

Anticipated

Primary completion date

Jul, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

1. Between 18 and 55-years-old.
2. BMI between 18 and 35 kg/m2.
3. Score a 4 or above on the Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist Part A.
4. Meet diagnostic criteria for ADHD with a current severity rating of at least mild as defined by the DIAMOND.
5. Are not pregnant or currently breastfeeding.
6. Have no history of significant allergic condition, hypersensitivity, or allergic reactions to cannabis, cannabinoid medications, hemp products, medium chain triglyceride oil, or peppermint.
7. Have not used CBG or any other cannabinoid products in the past 30 days.
8. Willing to abstain from using cannabis or any THC-containing product for the duration of the study.
9. Have never used a synthetic cannabinoid or cannabinoid analogue (e.g., dronabinol, nabilone), or a synthetic cannabinoid receptor agonist (e.g., spice, k2).
10. Have not been exposed to any investigational drug or device 30 days prior to screening and you have no plans to take an investigational drug during the study.
11. Willing to maintain a stable treatment regimen (i.e., no change in current medication use) for the duration of the study.
12. Not currently taking a prescription medication for ADHD and have not been prescribed a medication for ADHD in the past six months.
13. Not currently having thoughts of committing suicide
14. Does not meet criteria for current severe major depressive disorder or a substance use disorder.
15. Have not been diagnosed with bipolar disorder or psychosis.
16. Do not have an acute illness, such as a respiratory infection or other illness that would interfere with study participation; not currently taking medication for an acute illness (e.g., antibiotic).
17. Do not have history of diagnosis related to liver function and/or significantly impaired liver function (e.g., cirrhosis of the liver, hepatitis).
18. Willing to ensure they have used effective contraception (for example, oral contraception, double barrier, intra-uterine device) for 30 prior to the study and for 30 days after study completion.
19. Have access to a ride to the University of Arkansas campus for research appointments.
20. Willing to comply with current university mandates as they pertain to COVID-19 protocols (e.g., mask wearing).
21. Do not have any serious or unstable physical health conditions including neurological or renal illness.
22. Do not have any current or historical cardiovascular conditions, including hypotension, bradycardia, or heart block.
23. No atrial fibrillation, bradycardia, or tachycardia detected via mobile electrocardiogram during the in-laboratory visit.
24. No recent illicit drug use other than cannabis, or alcohol use in the 12 hours preceding the in-laboratory visit.
25. Not currently prescribed or taking the following medications:

  • Warfarin
  • Clobazam
  • Valproic acid
  • Phenobarbital
  • Mechanistic Target of Rapamycin \[mTOR\] Inhibitors
  • Oral tacrolimus
  • St. John's wort
  • Epidiolex
  • Escitalopram
  • Cardiovascular medications
  • Strong CYP3A4 inhibitors (e.g., ketoconazole)

Study Design

Enrollment

76 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Cannabigerol

1mL of 80mg of Cannabigerol. Cannabigerol is a safe, legal, non-high-inducing cannabinoid obtained from the cannabis plant.

placebo comparator: Placebo

1mL of Placebo. Placebo is made in the form of MCT oil.

Interventions

Cannabigerol

1 mL of 80mg Cannabigerol once during experimental session

Placebo

1 mL of placebo once during experimental session

Primary outcome measure

  • Sustained Attention to Response Task [ Time Frame: 75 minutes post CBG/placebo administration ]
  • Trail Making Test-Parts A and B (TMT-A&B) [ Time Frame: 75 minutes post CBG/placebo administration ]
  • Digit Symbol Substitution Test (DSST) [ Time Frame: 75 minutes post CBG/placebo administration ]
  • Rey Auditory Verbal Learning Test (AVLT) [ Time Frame: 75 minutes post CBG/placebo administration ]
  • Iowa Gambling Task (IGT) [ Time Frame: 75 minutes post CBG/placebo administration ]

Central Contacts and Locations

Central contacts

Ellen W Leen-Feldner, PhD

4795754256eleenfe@uark.edu

Locations

University of Arkansas

Recruiting

Fayetteville, Arkansas, United States, 72703

Contacts

Ellen Leen-Feldner, PhD

eleenfe@uark.edu

More Information

Sponsor

University of Arkansas, Fayetteville

Last update posted

May 27, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-09. This information was provided to ClinicalTrials.gov by University of Arkansas, Fayetteville on 2026-05-27. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.