Recruiting

Observational Study

Sponsor:

National Institute of Allergy and Infectious Diseases (NIAID)

Code:

NCT06120244

Conditions

Healthy

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Background:

Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat. Many of these viruses infect people by penetrating the thin skin that lines the nose. These viruses can also spread easily to other people when they multiply in the tissues that line the nose. Researchers want to learn more about what these viruses do inside the nose, how they get from the nose to the lungs, and how they spread from person to person.

Objective:

To collect cell samples from inside the noses of healthy people. These cells will be stored for use in future research on respiratory diseases.

Eligibility:

Healthy volunteers aged 18 years and older.

Design:

Most participants will have 1 visit on 1 day. They will be asked questions. Those who have a runny nose, coughing, congestion, or fever will be asked to wait up to 21 days before participating.

Participants will be given a slender swab with small bristles at the end. They will rub the inside of their nose with the swab. A clinic staff member will be present to help, if needed.

Participants will provide their name, age, and sex. This information will be encoded so that only certain researchers will know the participants identities.

Participants will not be contacted again....

Conditions

Healthy

Study ID

NCT06120244

Start date

Nov 1, 2023

Status verified date

Aug 10, 2026

Completion date

Oct 31, 2033

Anticipated

Primary completion date

Oct 31, 2033

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

  • Aged >=18 years.
  • Able to provide informed consent.
  • Willing to allow biological samples and data to be stored for future research.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this

study:

  • History of respiratory symptoms including but not limited to runny nose, coughing, congestion, and/or fever within the past 14 days.
  • NIH and laboratory staff with direct involvement in the operation or maintenance of the repository are excluded from participation.
  • An individual who has any condition that, in the judgment of the investigator, may put them at undue risk or make them unsuitable for participation in the study will be excluded.

Study Design

Enrollment

120 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy Volunteers

Healthy volunteers aged 18 years and older

Primary outcome measure

  • To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses. [ Time Frame: 10 years ]

Central Contacts and Locations

Central contacts

Emmie de Wit, Ph.D.

(406) 375-7490emmie.dewit@nih.gov

Locations

Rocky Mountain Laboratories

Recruiting

Hamilton, Montana, United States, 59840

Contacts

Emmie de Wit, Ph.D.

406-375-7490emmie.dewit@nih.gov

More Information

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Last update posted

Aug 12, 2026

Last verified

Aug 10, 2026

Keywords

  • Nasal Epithelium

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Institute of Allergy and Infectious Diseases (NIAID) on 2026-08-12.