Recruiting

Observational Study

Sponsor:

University of British Columbia

Code:

NCT06130033

Conditions

Circulatory Arrest

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Interventions

Neuromonitoring

Study Details

Brief summary:

The purpose of this study is to better understand what happens in the brain during the dying process.

This is a prospective observational study conducted at the end of life in the ICU at VGH. At the time of withdrawal of life sustaining therapies the investigators will monitor brain blood flow and oxygenation. The investigators will also collect blood samples to measure biomarkers of brain dysfunction.

This may help us to determine when blood flow to the brain stops and when brain function ceases. This information may provide researchers and the medical community as a whole with important information as to the best timing for organ donation. This study is the first step in commencing a research program related to improving the organ donation process. Our goal is to determine how best to provide high quality organs to those who would otherwise die without an organ transplant.

Conditions

Circulatory Arrest

Study ID

NCT06130033

Start date

Jun 1, 2023

Status verified date

Nov, 2024

Completion date

Jun 1, 2026

Anticipated

Primary completion date

Jun 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • a) Age > 18 years
  • b) anticipated withdrawal of life-sustaining measures (WLSM) within the next 24 hours

Exclusion Criteria:

  • No in-situ arterial line
  • No legal authorized representative
  • Neurological brain death declared

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Interventions

Neuromonitoring

Multimodal Neuromonitoring:

Transcranial Doppler - middle cerebral artery blood flow velocity Jugular venous bulb oximetry - hemoglobin oxygen saturation at the jugular venous bulb Arterial blood pressure monitoring - mean arterial, systolic and diastolic pressure monitoring at the radial artery via an in situ radial arterial line catheter Pulmonary artery catheter - to measure continuous cardiac output and mixed venous oxygen saturation Near infrared spectroscopy - to measure regional cerebral saturation of oxygen

Primary outcome measure

  • Cerebral Hemodynamics [ Time Frame: Up to 52 weeks ]

Central Contacts and Locations

Central contacts

Mypinder Sekhon, MD PhD

6048754111myp@mail.ubc.ca

Rebecca Grey, BSc

604-875-4111Rebecca.Grey@vch.ca

Locations

Vancouver General Hospital

Recruiting

Vancouver, British Columbia, Canada, V5Z1M9

Contacts

Mypinder Sekhon, MD PhD

6048754111myp@mail.ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Nov 13, 2024

Last verified

Nov, 2024

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2024-11-13.