Recruiting

Carbon Dioxide Gas

Sponsor:

University of Alabama at Birmingham

Code:

NCT06134154

Conditions

Abdominal Pain

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Interventions

Endoscopic insufflation gas

Study Details

Brief summary:

The goal of this clinical trial is to compare the efficacy and safety of air versus carbon dioxide gas insufflation for endoscopy in children.

The main question\[s\] it aims to answer are:

•to determine safety of CO2 Assess patient comfort (abdominal pain, flatulence and bloating) with CO2 use when compared to air.

Conditions

Abdominal Pain

Study ID

NCT06134154

Start date

Jan 24, 2024

Status verified date

Jan, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

\- Infants and children 6 months to 18 years undergoing any upper endoscopy related procedure including but not limited to EGD/Colonoscopy, ERCP, EGD only, EUS, EGD with foreign body removal, Enteroscopy.

Exclusion Criteria:

  • Patients with American Society of Anesthesiology (ASA) Physical Status Classification System of 4 and above
  • Children with chronic lung disease,
  • Children who are wards of the state will be excluded.
  • Children needing language interpreting services that is not Spanish.

Study Design

Enrollment

350 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

placebo comparator: Air

experimental: Carbondioxide

Interventions

Endoscopic insufflation gas

Carbon dioxide gas versus air for endoscopic insufflation

Primary outcome measure

  • Abdominal Pain [ Time Frame: baseline/ pre-procedure to immediately after the procedure ]

Central Contacts and Locations

Central contacts

Chinenye R Dike, MD MS

205 638 9918cdike@uabmc.edu

Locations

University of Alabama at Birmingham

Recruiting

Birmingham, Alabama, United States, 35233

Contacts

Chinenye R Dike, MD

3345585519cdike@uabmc.edu

More Information

Sponsor

University of Alabama at Birmingham

Last update posted

Jan 23, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alabama at Birmingham on 2026-01-23.