Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT06135870

Conditions

Fibroid

Leiomyoma

Eligibility Criteria

Sex: Female

Age: 18 - 55

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The investigators are evaluating the role of senescent cells in uterine fibroids.

Conditions

Fibroid

Leiomyoma

Study ID

NCT06135870

Start date

Nov 1, 2023

Status verified date

Dec, 2025

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Subjects must be women above the age of ≥18 - ≤55 years.
  • Women with suspected uterine fibroids.
  • Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
  • Subject must be able to understand, read and speak English or Spanish and subsequently, be able to understand what she is consenting to in terms of procedures and use/disclosure of protected health information.

Exclusion Criteria:

  • Unwilling to sign the consent form or complete questionnaire.
  • Pregnancy.
  • Cancer of the uterus

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Arms

Women with fibroids undergoing elective hysterectomy or myomectomy

Women between the age of 18-55 with fibroids undergoing elective hysterectomy or myomectomy

Primary outcome measure

  • Develop an atlas to comprehensively quantify the rate of senescent cell (SnC) types in fibroid and myometrium tissue samples [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

James Segars, MD

410-614-2000jsegars2@jhmi.edu

Bhuchitra Singh, MD, MPH, MBA

410-614-2000bsingh10@jhmi.edu

Locations

Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Rachel Mitchel

rmiche10@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Dec 11, 2025

Last verified

Dec, 2025

Keywords

  • Senescent cells
  • Fibroids
  • Leiomyomas

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2025-12-11.