Recruiting

Nutritional Supplement

Sponsor:

UCLA

Code:

NCT06138106

Conditions

Dietary Supplements

Connective Tissue

Exercise

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Interventions

Natural Product Supplement

Placebo control

Study Details

Brief summary:

The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samples will be used to treat human engineered ligaments.

Conditions

Dietary Supplements

Connective Tissue

Exercise

Study ID

NCT06138106

Start date

Nov 21, 2023

Status verified date

Jun, 2026

Completion date

Dec 1, 2026

Anticipated

Primary completion date

Dec 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 30

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Young healthy adults (18-30 y)

Exclusion Criteria:

  • Pregnancy
  • Smoking
  • Receiving any medication that may interfere with the study outcomes

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Natural Product Supplement

The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg), epicatechin (75 mg), vitamin E (350 iU) and stevia extract (225 mg).

placebo comparator: Placebo

The participant will consume a dose of hydrolyzed collagen (20g) supplemented with vitamin C (100 mg) and sweetener.

Interventions

Natural Product Supplement

Participants will have blood drawn before and one hour after consuming the natural product supplement. For 7-days the participants will perform load-bearing exercise and consume the supplement. On the final day, blood will be collected 4 hours after the final exercise bout.

Placebo control

Participants will have blood drawn before and one hour after consuming the placebo supplement. For 7-days the participants will perform load-bearing exercise and consume the supplement. On the final day, blood will be collected 4 hours after the final exercise bout.

Primary outcome measure

  • Collagen protein synthesis [ Time Frame: 7 days ]

Central Contacts and Locations

Central contacts

Kevin Paulussen, PhD

2177214479kpaulussen@ucdavis.edu

Locations

Hickey Laboratory

Recruiting

Davis, California, United States, 95616

Contacts

Kevin Paulussen, PhD

kpaulussen@ucdavis.edu

Keith Baar, PhD

kbaar@ucdavis.edu

More Information

Sponsor

University of California, Davis

Last update posted

Jun 29, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Davis on 2026-06-29.