Recruiting
Phase 3

Elranatamab

Sponsor:

Pfizer

Code:

NCT06152575

Conditions

Multiple Myeloma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Elranatamab

Elotuzumab

Pomalidomide

Dexamethasone

Bortezomib

Study Details

Brief summary:

The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer).

This study is seeking participants who:

  • Are 18 years of age or older and have MM.
  • Have received treatments before for MM.
  • Have MM that has returned or not responded to their most recent treatment.

Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM.

Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study.

The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as:

  • a shot under the skin at the study clinic
  • through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects.

Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits).

The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.

Conditions

Multiple Myeloma

Study ID

NCT06152575

Start date

Feb 8, 2024

Status verified date

Aug, 2026

Completion date

Dec 30, 2027

Anticipated

Primary completion date

Aug 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Prior diagnosis of multiple myeloma as defined by International Myeloma Working Group (IMWG) criteria and previously received 1 to 4 prior lines of therapy including prior anti-cluster of differentiation 38 (CD38) antibody and prior lenalidomide.
  • Documented evidence of progressive disease or failure to achieve a response to last line of therapy per IMWG criteria.
  • Measurable disease defined as at least 1 of the following: (a) Serum M-protein ≥0.5 g/dL; (b) Urinary M-protein excretion ≥200 mg/24 hours; (c) Serum involved immunoglobulin FLC ≥10 mg/dL AND abnormal serum immunoglobulin kappa to lambda FLC ratio (<0.26 or >1.65).
  • Have clinical laboratory values within the specified range.
  • ECOG (Eastern Cooperative Oncology Group) performance status ≤2.
  • Not pregnant or breastfeeding and willing to use contraception.

Exclusion Criteria:

  • Smoldering multiple myeloma.
  • Plasma cell leukemia.
  • Amyloidosis.
  • Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin abnormalities (POEMS) syndrome.
  • Known central nervous system (CNS) involvement or clinical signs of myelomatous meningeal involvement.
  • Stem cell transplant within 12 weeks prior to enrolment, or active graft versus host disease.
  • Any active, uncontrolled bacterial, fungal, or viral infection.
  • Any other active malignancy within 3 years prior to enrolment (exceptions include, adequately treated basal cell or squamous cell skin cancer, carcinoma in situ)
  • Previous treatment with a B cell maturation antigen (BCMA)-directed therapy or CD3-redirecting therapy.
  • Unable to receive investigator's choice therapy.
  • Live attenuated vaccine within 4 weeks of the first dose of study intervention.
  • Administration with an investigational product (e.g. drug or vaccine) within 30 days preceding the first dose of study intervention used in this study.

Study Design

Enrollment

492 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Elranatamab

Participants will receive elranatamab monotherapy

active comparator: Investigator's Choice

Participants will receive either Elotuzumab, Pomalidomide and Dexamethasone (EPd), or Pomalidomide, Bortezomib and Dexamethasone (PVd), or Carfilzomib and Dexamethasone (Kd)

Interventions

Elranatamab

Elranatamab will be administered subcutaneously

Elotuzumab

Elotuzumab will be administered intravenously

Pomalidomide

Pomalidomide will be administered orally

Dexamethasone

Dexamethasone will be administered orally

Bortezomib

Bortezomib will be administered subcutaneously or intravenously

Carfilzomib

Carfilzomib will be administered intravenously

Primary outcome measure

  • Progression free survival per International Myeloma Working Group criteria [ Time Frame: Up to approximately 5 years ]

Central Contacts and Locations

Central contacts

Pfizer CT.gov Call Center

1-800-718-1021ClinicalTrials.gov_Inquiries@pfizer.com

Locations

Infirmary Cancer Care

Recruiting

Mobile, Alabama, United States, 36607

Beverly Hills Cancer Center

Recruiting

Beverly Hills, California, United States, 90211

Clovis Community Medical Center

Recruiting

Clovis, California, United States, 93611

Community Cancer Institute

Recruiting

Clovis, California, United States, 93611

Clinical Research Advisors (Encino Satellite Location)

Recruiting

Encino, California, United States, 91316

University of California San Francisco

Recruiting

Fresno, California, United States, 93701

Community Regional Medical Center

Recruiting

Fresno, California, United States, 93721

Clinical Research Advisors (Korea Town Satellite Location)

Recruiting

Los Angeles, California, United States, 90020

Clinical Research Advisors (West Hollywood Satellite Location)

Recruiting

Los Angeles, California, United States, 90048

Valkyrie Clinical Trials

Recruiting

Los Angeles, California, United States, 90067

Mission Community Hospital (Satellite Site)

Recruiting

Panorama City, California, United States, 91402

University of California Davis (UC Davis) Comprehensive Cancer Center

Recruiting

Sacramento, California, United States, 95817

University of California

Recruiting

Sacramento, California, United States, 95817

UCHealth Poudre Valley Hospital

Recruiting

Fort Collins, Colorado, United States, 80524

UCHealth Harmony

Recruiting

Fort Collins, Colorado, United States, 80528

UCHealth Greeley Hospital

Recruiting

Greeley, Colorado, United States, 80634

UCHealth Longs Peak Hospital

Recruiting

Longmont, Colorado, United States, 80504

UCHealth Longs Peak Medical Center

Recruiting

Longmont, Colorado, United States, 80504

UCHealth - Medical Center of the Rockies

Recruiting

Loveland, Colorado, United States, 80538

Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center

Recruiting

Coral Gables, Florida, United States, 33146

University of Miami Hospital and Clinics - Deerfield Beach

Recruiting

Deerfield Beach, Florida, United States, 33442

Sylvester Comprehensive Cancer Center- Doral

Recruiting

Doral, Florida, United States, 33166

Sylvester Comprehensive Cancer Center - Hollywood

Recruiting

Hollywood, Florida, United States, 33021

Sylvester Comprehensive Cancer Center

Recruiting

Miami, Florida, United States, 33136

University of Miami Hospital and Clinics - Griffin Cancer Research Building

Recruiting

Miami, Florida, United States, 33136

University of Miami Hospital and Clinics

Recruiting

Miami, Florida, United States, 33136

Baptist Hospital of Miami

Recruiting

Miami, Florida, United States, 33176

Miami Cancer Institute at Baptist Health, Inc.

Recruiting

Miami, Florida, United States, 33176

Sylvester Comprehensive Cancer Center- Kendall

Recruiting

Miami, Florida, United States, 33176

BRCR Global

Recruiting

Plantation, Florida, United States, 33322

BRCR Medical Center Inc

Recruiting

Plantation, Florida, United States, 33322

Brcr Medical Center, Inc.

Recruiting

Plantation, Florida, United States, 33322

HCA Florida Westside Hospital

Recruiting

Plantation, Florida, United States, 33324

BRCR Medical Center Inc.

Recruiting

Tamarac, Florida, United States, 33321

Endeavor Health - Swedish Hospital

Recruiting

Chicago, Illinois, United States, 60625

Endeavor Health - Evanston Hospital

Recruiting

Evanston, Illinois, United States, 60201

Endeavor Health - Glenbrook Hospital Ambulatory Care Center

Recruiting

Glenview, Illinois, United States, 60026

Endeavor Health - Highland Park Hospital Health Center 1

Recruiting

Highland Park, Illinois, United States, 60035

Simmons Cancer Institute at SIU

Recruiting

Springfield, Illinois, United States, 62702

Springfield Clinic Main Campus

Recruiting

Springfield, Illinois, United States, 62703

HSHS St. John's Hospital

Recruiting

Springfield, Illinois, United States, 62769

Springfield Memorial Hospital

Recruiting

Springfield, Illinois, United States, 62781

Midwestern Regional Medical Center, Inc. dba City of Hope Chicago

Recruiting

Zion, Illinois, United States, 60099

Community Health Network, Inc.

Recruiting

Indianapolis, Indiana, United States, 46227

Community Health Network, Inc.

Recruiting

Indianapolis, Indiana, United States, 46250

Community Health Network, Inc.

Recruiting

Indianapolis, Indiana, United States, 46256

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Recruiting

Kansas City, Kansas, United States, 66112

Ascentist Doctors' Hospital

Recruiting

Leawood, Kansas, United States, 66211

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Recruiting

Merriam, Kansas, United States, 66204

Beth Israel Deaconess Medical Center

Recruiting

Boston, Massachusetts, United States, 02215

BIDMC Research Pharmacy

Recruiting

Boston, Massachusetts, United States, 02215

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Recruiting

Belton, Missouri, United States, 64012

MIVA Medical

Recruiting

Independence, Missouri, United States, 64057

Kansas City VA Medical Center

Recruiting

Kansas City, Missouri, United States, 64128

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Recruiting

Kansas City, Missouri, United States, 64132

Bryan Medical Center

Recruiting

Lincoln, Nebraska, United States, 68506

NHO Revive Research Institute, LLC

Recruiting

Lincoln, Nebraska, United States, 68506

Atlantic Health System Morristown Medical Center

Recruiting

Morristown, New Jersey, United States, 07960

Northwell Health/ RJ Zuckerberg Cancer Center

Recruiting

Lake Success, New York, United States, 11042

North Shore University Hospital

Recruiting

Manhasset, New York, United States, 11030

Long Island Jewish Medical Center

Recruiting

New Hyde Park, New York, United States, 11040

Sanford Fargo Medical Center

Recruiting

Fargo, North Dakota, United States, 58102

Oncology Hematology Care Clinical Trials, LLC

Recruiting

Cincinnati, Ohio, United States, 45211

TriHealth Cancer Institute-Good Samaritan Hospital

Recruiting

Cincinnati, Ohio, United States, 45220

Oncology Hematology Care Clinical Trials, LLC

Recruiting

Cincinnati, Ohio, United States, 45236

The Jewish Hospital

Recruiting

Cincinnati, Ohio, United States, 45236

Oncology Hematology Care Clinical Trials, LLC

Recruiting

Cincinnati, Ohio, United States, 45242

TriHealth Cancer Institute- Thomas Comprehensive Care Center

Recruiting

Cincinnati, Ohio, United States, 45242

Oncology Hematology Care Clinical Trials, LLC

Recruiting

Cincinnati, Ohio, United States, 45245

Cleveland Clinic

Recruiting

Cleveland, Ohio, United States, 44195

AHN West Penn Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15224

Rodhe Island Hospital

Recruiting

Providence, Rhode Island, United States, 02903

The Miriam Hospital

Recruiting

Providence, Rhode Island, United States, 02906

Ascension St. Thomas Hospital

Recruiting

Nashville, Tennessee, United States, 37203

Tennessee Oncology, PLLC - Investigational Drug Services

Recruiting

Nashville, Tennessee, United States, 37203

Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Center for Blood Cancers

Recruiting

Nashville, Tennessee, United States, 37203

Tennessee Oncology, PLLC - Nashville Elliston Place Plaza DDU

Recruiting

Nashville, Tennessee, United States, 37203

Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Medical Oncology & Hematology

Recruiting

Nashville, Tennessee, United States, 37203

Baylor University Medical Center, Investigational Drug Services, Department of Pharmacy

Recruiting

Dallas, Texas, United States, 75246

Baylor University Medical Center

Recruiting

Dallas, Texas, United States, 75246

Houston Methodist Cancer Center Infusion

Recruiting

Houston, Texas, United States, 77030

Houston Methodist Hospital - Department of Pharmacy

Recruiting

Houston, Texas, United States, 77030

Houston Methodist Hospital Cancer Center

Recruiting

Houston, Texas, United States, 77030

Houston Methodist Clear Lake Hospital (St. John)

Recruiting

Houston, Texas, United States, 77058

Houston Methodist Willowbrook Hospital

Recruiting

Houston, Texas, United States, 77070

Houston Methodist West Hospital

Recruiting

Houston, Texas, United States, 77094

Joe Arrington Cancer Research and Treatment Center

Recruiting

Lubbock, Texas, United States, 79410

Houston Methodist Sugar Land Hospital

Recruiting

Sugar Land, Texas, United States, 77479

Baylor Scott & White Medical Center - Temple

Recruiting

Temple, Texas, United States, 76508

Houston Methodist The Woodlands Hospital

Recruiting

The Woodlands, Texas, United States, 77385

WVU Cancer Institute

Recruiting

Morgantown, West Virginia, United States, 26506

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Recruiting

Madison, Wisconsin, United States, 53718

University of Wisconsin Carbone Cancer Center-University Hospital

Recruiting

Madison, Wisconsin, United States, 53792

The Moncton Hospital

Recruiting

Moncton, New Brunswick, Canada, E1C 6Z8

Jewish General Hospital

Recruiting

Montreal, Quebec, Canada, H3T 1E2

l'Hôpital du Sacré-Cœur-de-Montréal

Recruiting

Montreal, Quebec, Canada, H4J 1C5

More Information

Sponsor

Pfizer

Last update posted

Aug 24, 2026

Last verified

Aug, 2026

Keywords

  • Elranatamab
  • B-Cell Maturation Antigen
  • BCMA
  • Bispecific antibody
  • BCMA-CD3 bispecific antibody
  • Myeloma
  • Multiple myeloma
  • Relapsed multiple myeloma
  • Refractory multiple myeloma
  • MagnetisMM
  • MagnetisMM-32
  • Pomalidomide
  • Elotuzumab
  • Bortezomib
  • Carfilzomib
  • PF-06863135

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Pfizer on 2026-08-24.