Recruiting

Voice Therapy

Sponsor:

UCLA

Code:

NCT06165536

Conditions

Mid-membranous Vocal Fold Lesion

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Not accepted

Interventions

Resonant voice therapy

Study Details

Brief summary:

Phonotraumatic vocal hyperfunction is one of the most frequently occurring conditions to affect the voice. This voice disorder often involves vocal fold injury due to repeated, excessive contact pressure between the vocal folds when they collide during voice production. In the clinic, voice therapy attempts to modify unhealthy vocal behaviors through different techniques or exercises. While voice therapy is generally considered effective, the scientific rationale for its therapeutic benefits still remains unclear. It is generally believed that these exercises lead to adjustments in the larynx and vocal tract that reduce vocal fold contact pressure. However, this assumption has never been tested in humans or laboratory experiments. The goal of this clinical trial is to investigate the effectiveness of voice therapy in reducing vocal fold contact pressures and in eliciting the hypothesized favorable laryngeal and vocal tract configurations.

Conditions

Mid-membranous Vocal Fold Lesion

Study ID

NCT06165536

Start date

Dec 1, 2025

Status verified date

Dec, 2025

Completion date

Jan 31, 2028

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Ages 18-40 years (to minimize developmental changes associated with adolescent and elderly age)
  • Clinic diagnosis by a fellowship trained laryngologist of mid-membranous lesions that by history and appearance are phonotraumatic
  • Must be referred for voice therapy

Exclusion Criteria:

  • Medical comorbidities (e.g., autoimmune disorders) beyond seasonal allergy and laryngopharyngeal reflux
  • Vocal fold lesions generally regarded to be less responsive to voice therapy (e.g. vocal fold cysts).
  • Claustrophobia
  • Inability to replicate fundamental frequencies required for the study at the intensity levels determined

Study Design

Enrollment

60 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Voice therapy

Resonant voice therapy is a standard of care procedure for treating phonotraumatic vocal hyperfunction. The full standardized voice therapy program will have a duration of four weeks, each week with one 60-minute therapy session.

Interventions

Resonant voice therapy

Resonant voice therapy is a standard of care procedure for treating phonotraumatic vocal hyperfunction. The full standardized voice therapy program will have a duration of four weeks, each week with one 60-minute therapy session.

Primary outcome measure

  • Voice handicap index (VHI-10) [ Time Frame: 30 minutes before the first voice therapy session, and 30 minutes after the last session of the 4-week voice therapy ]
  • Severity of vocal fold lesions [ Time Frame: 30 minutes before the first voice therapy session, and 30 minutes after the last session of the 4-week voice therapy ]

Central Contacts and Locations

Central contacts

Locations

UCLA Rehab Center

Recruiting

Los Angeles, California, United States, 90095

Contacts

Zhaoyan Zhang

310-206-4324

Principal Investigator:

Zhaoyan Zhang

More Information

Sponsor

University of California, Los Angeles

Last update posted

Dec 15, 2025

Last verified

Dec, 2025

Keywords

  • Vocal fold lesion
  • Vocal hyperfunction

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2025-12-15.