Recruiting

Stuttering

Sponsor:

Arizona State University

Code:

NCT06181149

Conditions

Healthy Subjects

Stuttering, Developmental

Eligibility Criteria

Sex: All

Age: 3+

Healthy Volunteers: Accepted

Interventions

Delaying speech initiation

Auditory errors and pre-speech auditory modulation

Contributions of the speech premotor cortex to pre-speech auditory modulation

Delaying auditory feedback

Study Details

Brief summary:

Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words/sentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking.

Conditions

Healthy Subjects

Stuttering, Developmental

Study ID

NCT06181149

Start date

Jan 1, 2024

Status verified date

Aug, 2025

Completion date

Dec 30, 2027

Anticipated

Primary completion date

Dec 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 3+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • being a monolingual, native speaker of American English
  • absence of developmental, psychological, neurological, or communication disorders (other than developmental stuttering) as confirmed by a certified research SLP
  • normal (age-appropriate) binaural pure-tone hearing threshold (0.5-4k Hz; ≤25 dB HL for younger than 70 years, and ≤35 dB HL for older than 70 years)
  • not taking any medications that affect the central nervous system
  • absence of safety contra-indication for tDCS, TMS and MRI (for adults)
  • scoring at the 20th percentile or higher on standardized speech-language tests (for children)

Exclusion Criteria:

\-

Study Design

Enrollment

300 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Group 1

experimental: Group 2

experimental: Group 3

experimental: Group 4

Interventions

Delaying speech initiation

This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use transcranial magnetic stimulation to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.

Auditory errors and pre-speech auditory modulation

This intervention will examine the contributions of auditory errors to pre-speech auditory modulation. Participants will receive auditory perturbations while speaking, and we will collect their brain activities throughout the study.

Contributions of the speech premotor cortex to pre-speech auditory modulation

This intervention will examine the effects of stimulation of the left ventral premotor cortex on pre-speech auditory modulation. Participants will receive electrical stimulation while speaking.

Delaying auditory feedback

This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use delayed auditory feedback to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.

Primary outcome measure

  • Change in brain activity before and during speaking [ Time Frame: within each session of the study that may last up to 2 hours ]
  • change in speech when participants experience auditory errors [ Time Frame: within each session of the study that may last up to 2 hours ]

Central Contacts and Locations

Central contacts

Ayoub Daliri, PhD

4807278397ayoub.daliri@asu.edu

Locations

Arizona State University

Recruiting

Tempe, Arizona, United States, 85287

Contacts

Ayoub Daliri

480-727-8397ayoub.daliri@asu.edu

Principal Investigator:

Ayoub Daliri, PhD

Univeristy of Washington

Recruiting

Seattle, Washington, United States, 98105

Contacts

Ludo Max

206-543-2674MaxLab@uw.edu

Principal Investigator:

Ludo Max, PhD

More Information

Sponsor

Arizona State University

Last update posted

Aug 21, 2025

Last verified

Aug, 2025

Keywords

  • stuttering

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-11. This information was provided to ClinicalTrials.gov by Arizona State University on 2025-08-21.