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Not recruiting

Cycling & Virtual Reality

Sponsor:

Kessler Foundation

Code:

NCT06191380

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Interventions

PACE-MS

Study Details

Brief summary:

To compare the effects of cycling exercise with different types of virtual reality on processing/thinking speed in persons with multiple sclerosis (MS).

Conditions

Multiple Sclerosis

Study ID

NCT06191380

Start date

Feb 12, 2024

Status verified date

Jan, 2025

Completion date

Sep 30, 2025

Anticipated

Primary completion date

Sep 30, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Speak English as their primary language
  • Confirmed MS diagnosis by a neurologist
  • Be relapse and steroid-free for at least 30 days
  • Mild-to-moderate self-report mobility disability

Exclusion Criteria:

  • History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
  • Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
  • Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
  • Currently pregnant
  • Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)
  • No indication of age-related mild cognitive impairment or dementia, based on the MOCA-Blind (i.e., MOCA-Blind ≥19).
  • High likelihood of motion sickness
  • Regular cyclist, defined as cycling for at least 150 minutes/week

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Cycling Alone

Cycling alone, with no virtual reality.

experimental: Cycling with Visually Stimulating VR

Cycling with virtual reality where I only have to look at the environment while I cycle.

experimental: Cycling with Cognitively Stimulating VR

Cycling with virtual reality where I have to complete a thinking task while cycling in the virtual environment.

Interventions

PACE-MS

A single bout of cycling.

Primary outcome measure

  • Modified Flanker Task (MFT) [ Time Frame: Immediately before the single bout of cycling and 5 minutes after the single bout of cycling. ]

Central Contacts and Locations

Central contacts

Carly Wender, PhD

9733248388cwender@kesslerfoundation.org

Locations

Kessler Foundation

Recruiting

East Hanover, New Jersey, United States, 07936

Contacts

Carly Wender, PhD

9732436984cwender@kesslerfoundation.org

More Information

Sponsor

Kessler Foundation

Last update posted

Sep 2, 2025

Last verified

Jan, 2025

Keywords

  • Multiple Sclerosis
  • Leg Cycling
  • Virtual Reality
  • Mobility Disability
  • Processing Speed

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-12. This information was provided to ClinicalTrials.gov by Kessler Foundation on 2025-09-02.