Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT06195059

Conditions

Heart Failure

Pulmonary Vascular Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to evaluate whether pulmonary blood volume (PBV) derived from contrast echocardiography can serve as a non-invasive surrogate for invasive pulmonary artery wedge pressure (PAWP) during exercise. Also, to compare changes in PBV with exercise in patients with and without heart failure and pulmonary vascular disease.

Conditions

Heart Failure

Pulmonary Vascular Disease

Study ID

NCT06195059

Start date

Jul 30, 2024

Status verified date

Aug, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients referred to the cardiac catheterization laboratory for invasive exercise right heart catheterization for evaluating exertional dyspnea. Investigators will include patients with normal or low EF, and across the spectrum of pulmonary hypertension severity.

Exclusion Criteria:

  • Patient inability or unwillingness to undergo echocardiography including a contrast method, or if echocardiography would, in the opinion of the investigator, somehow compromise the quality of data acquisition for the clinical case.
  • Prior adverse reaction to echo contrast administration

Study Design

Enrollment

800 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Pulmonary Vascular Capacitance at Rest [ Time Frame: Baseline ]
  • Pulmonary Vascular Capacitance During Exercise [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Circulatory Failure Research Team

507-255-2200

Barry Borlaug, MD

507-255-2142Borlaug.Barry@mayo.edu

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Circulatory Failure Research Team

507-255-2200

Barry Borlaug, MD

507-255-2142Borlaug.Barry@mayo.edu

Principal Investigator:

Barry Borlaug, MD

More Information

Sponsor

Mayo Clinic

Last update posted

Aug 20, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-08-20.