Recruiting

Anesthesia

Sponsor:

Children's Hospital Los Angeles

Code:

NCT06195345

Conditions

HIE

TBI (Traumatic Brain Injury)

TBI

Hemodynamic Instability

Hypoxic-Ischemic Encephalopathy

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Accepted

Interventions

MR Imaging

Study Details

Brief summary:

This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.

Conditions

HIE

TBI (Traumatic Brain Injury)

TBI

Hemodynamic Instability

Hypoxic-Ischemic Encephalopathy

Study ID

NCT06195345

Start date

Nov 1, 2018

Status verified date

Apr, 2026

Completion date

Nov 1, 2035

Anticipated

Primary completion date

Nov 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Individuals who are able to tolerate an MRI.
  • Are patients scheduled for a clinically indicated MRI.
  • Between birth and up to 18 years.

Exclusion Criteria:

  • Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents)
  • Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI.
  • Preterm infants less than 25 weeks
  • Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Pediatric Patients

Children scheduled for clinical MR imaging.

Interventions

MR Imaging

MR imaging pertaining to the patient and project (ICHOR 1)

Primary outcome measure

  • Change in cerebral blood flow (ml blood/100g/min) [ Time Frame: Time points over which the change is assessed: change from (1) start of MRI, through (2) MRI completion, an average of 60 minutes. ]
  • Change in cerebral metabolic rate of oxygen (ml O2/100g/min) [ Time Frame: Time points over which the change is assessed: change from (1) start of MRI, through (2) MRI completion, an average of 60 minutes. ]

Central Contacts and Locations

Central contacts

Hannah E Wiseman, MPH

323-361-3963hwiseman@chla.usc.edu

Matthew T Borzage, PhD

323-601-5757mborzage@chla.usc.edu

Locations

Children's Hospital Los Angeles

Recruiting

Los Angeles, California, United States, 90027

Contacts

Gabriel Luna

323-361-8791hspp@chla.usc.edu

More Information

Sponsor

Children's Hospital Los Angeles

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Children's Hospital Los Angeles on 2026-04-29.