Recruiting

THRIVE Pathway

Sponsor:

University of Pennsylvania

Code:

NCT06203509

Conditions

Care Transitions

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Thrive Intervention

Study Details

Brief summary:

This study aims to evaluate the THRIVE clinical pathway at HUP, focusing on supporting Medicaid-insured individuals, including those with serious mental illness, following hospitalization. The study will assess clinician/administrator perspectives on the pathway's feasibility, appropriateness, and acceptability and analyze referral patterns and post-discharge outcomes.

The objectives are:

1. To conduct a qualitative study evaluating the implementation of THRIVE, particularly its adaptation to include patients with serious mental illness.
2. To examine referral patterns, 30-day readmission rates, and ED utilization for THRIVE participants, comparing them with those receiving standard care.

Participants will be referred to home care services during hospitalization and seen by a home care nurse within 48 hours post-discharge. A discharging physician or Advanced Practice Provider will oversee care for 30 days or until a primary care or specialist visit. The Care Coordination Team will hold weekly case conferences for 30 days post-discharge to address both health and mental health needs. The study will compare outcomes of Medicaid-insured patients, including those with serious mental illness, to those receiving usual care.

Conditions

Care Transitions

Study ID

NCT06203509

Start date

Apr 15, 2024

Status verified date

Aug, 2026

Completion date

Dec 1, 2026

Anticipated

Primary completion date

Dec 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Medicaid insured
  • Residing in the state of Pennsylvania
  • Experienced a hospitalization at study hospital
  • Agrees to home care at partner home care setting.

Exclusion Criteria:

  • Individuals under age 18

Study Design

Enrollment

267 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: THRIVE Intervention

THRIVE Intervention

1-month intensive post discharge case management and care coordination

no intervention: Usual Care

Discharge to home without intensive post-acute case management or care coordination.

Interventions

Thrive Intervention

• The THRIVE Clinical Pathway is a standardized transitional care clinical pathway that supports Medicaid insured or Medicaid eligible individuals being managed for both chronic diseases and serious mental illness following hospitalization.

Primary outcome measure

  • Rates of Referrals to Homecare [ Time Frame: Through study completion, an average of 18 months ]
  • Rates of Readmissions [ Time Frame: 30 days following hospital discharge ]
  • Rates of Emergency Department Visit [ Time Frame: 30 days following hospital discharge ]
  • Primary Care or Specialist Visit [ Time Frame: 30 Days following hospital discharge ]

Central Contacts and Locations

Central contacts

Locations

Upenn School of Nursing Centre For Health Outcomes Policy Research

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Jacqueline M Brooks Carthon, PhD,RN

215-898-8050jmbrooks@nursing.upenn.edu

Kelvin Amenyedor, PhD,RN

2158984417kelvinam@upenn.edu

Principal Investigator:

Jacqueline M Brooks Carthon, PhD,RN

More Information

Sponsor

University of Pennsylvania

Last update posted

Aug 12, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2026-08-12.