Recruiting

Cardiac MRI

Sponsor:

Virginia Commonwealth University

Code:

NCT06212791

Conditions

Paroxysmal Atrial Fibrillation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Self- Report Evaluation-Duke Activity Status Index

Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire

Cardiopulmonary exercise test (CPET)

Transthoracic echocardiogram

Ambulatory cardiac rhythm assessment

Study Details

Brief summary:

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Conditions

Paroxysmal Atrial Fibrillation

Study ID

NCT06212791

Start date

Dec 26, 2024

Status verified date

Mar, 2026

Completion date

Mar, 2028

Anticipated

Primary completion date

Mar, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥18 years
  • Diagnosis of paroxysmal AF
  • Left ventricular ejection fraction ≥50%
  • Scheduled for catheter ablation
  • Able to speak, hear, and read English
  • Willing and able to provide informed consent

Exclusion Criteria:

  • Persistent or permanent AF
  • Prior ablation (catheter based or surgical) for AF
  • Significant sinus node dysfunction
  • Implanted pacemaker or defibrillator
  • Contraindication to or inability to complete cardiovascular magnetic resonance study
  • Contraindication to or inability to complete exercise testing
  • Chronic kidney disease with estimated glomerular filtration rate <30 mL/min/1.73m2
  • Severe left ventricular hypertrophy
  • Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:

  • Hypertrophic cardiomyopathy
  • Cardiac amyloidosis
  • Constrictive pericarditis
  • Pulmonary arterial hypertension
  • Prior cardiac surgery
  • Active pregnancy

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients under going catheter ablation

Patients undergoing catheter ablation for paroxysmal AF, reduction or elimination of arrhythmia burden

Interventions

Self- Report Evaluation-Duke Activity Status Index

Complete the Self- Report Evaluation-Duke Activity Status Index

Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire

Complete the Self- Report Evaluation, Atrial Fibrillation Effect on Quality of Life Questionnaire

Cardiopulmonary exercise test (CPET)

Cardiopulmonary exercise test (CPET)

Transthoracic echocardiogram

Transthoracic echocardiogram at rest and immediately following peak exercise during CPET

Ambulatory cardiac rhythm assessment

Ambulatory cardiac rhythm assessment

Cardiovascular magnetic resonance (CMR)

Cardiovascular magnetic resonance (CMR) study at rest and during two stages of submaximal exercise (ExeCMR)

Primary outcome measure

  • Change in LA reservoir function reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF. [ Time Frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation. ]

Central Contacts and Locations

Central contacts

Pamela Grizzard

804-628-6234pamela.grizzard@vcuhealth.org

Melissa Sears

804-828-1601melissa.sears@vcuhealth.org

Locations

Virginia Commonwealth University

Recruiting

Richmond, Virginia, United States, 23298

Contacts

Pamela Grizzard

804-628-6234pamela.grizzard@vcuhealth.org

Melissa Sears

804-828-1601melissa.sears@vcuhealth.org

More Information

Sponsor

Virginia Commonwealth University

Last update posted

Mar 12, 2026

Last verified

Mar, 2026

Keywords

  • Catheter ablation
  • Exercise capacity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Virginia Commonwealth University on 2026-03-12.