Observational Study

Sponsor:

BC Women's Hospital & Health Centre

Code:

NCT06215937

Conditions

Endometriosis

Pain

Eligibility Criteria

Sex: Female

Age: 19 - 49

Healthy Volunteers: Not accepted

Interventions

No Intervention

Study Details

Brief summary:

Endometriosis is a gynecologic condition where there is growth of endometrial-like tissue outside the uterus, leading to severe pelvic pain. Despite conventional treatment, many patients experience persistent pelvic pain due to central sensitization (CS), where the central nervous system amplifies pain signals. Quantitative Sensory Testing (QST) enables objective testing of CS. However, there are several patient-reported questionnaires that have shown promising potential as subjective proxies of CS.

Therefore, in this study, our objective is to validate six patient-reported questionnaires as measures of CS by comparing them to each other and determining whether each questionnaire correlates with QST thresholds.

Conditions

Endometriosis

Pain

Study ID

NCT06215937

Start date

May 1, 2024

Status verified date

Aug, 2026

Completion date

Apr 30, 2026

Primary completion date

Feb 28, 2026

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 19 - 49

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • New or re-referral appointment at the BC Women's Centre for Pelvic Pain and Endometriosis.
  • Consented to be contacted for future research in the centre data registry (EPPIC NCT02911090; H16-00264).
  • Surgically confirmed endometriosis, current imaging diagnosis, or current clinically suspected endometriosis diagnosed at the new or re-referral appointment as coded in the registry.
  • 19 to 49 years old.
  • Willing and committed to completing six questionnaires about pain.

QST specific criteria

• Willing and committed to QST testing.

Exclusion Criteria:

  • Currently pregnant or breastfeeding.
  • Post-menopausal.
  • Does not speak English - Patients who do not speak English will be excluded to maintain the safety and well-being of the patient, as not understanding the test and process may harm the patient and reduce the validity of the results. We do not have research funding for a translator. Additionally, patients who require a translator are not typically included in the data registry and therefore are unlikely to be in our sample.

QST specific criteria

  • Diabetes or neurological disease predisposing to neuropathic pain.
  • Previous laparotomy (i.e. large abdominal incision)
  • Physical trauma (ex., surgery, scaring) to heterotropic QST test site(s) (i.e. deltoid muscle in the shoulder, thenar eminence).

Study Design

Enrollment

126 participants

Interventions and Outcome Measures

Interventions

No Intervention

No intervention

Primary outcome measure

  • Central Sensitization [ Time Frame: Feb 1st 2023 - Jan 31st 2026 ]

Central Contacts and Locations

More Information

Sponsor

BC Women's Hospital & Health Centre

Last update posted

Sep 2, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-03. This information was provided to ClinicalTrials.gov by BC Women's Hospital & Health Centre on 2026-09-02.