Recruiting

Clopidogrel vs. TicagrelorDual Antiplatelet Therapy (DAPT) in Patients With Baseline Thrombocytopenia

Sponsor:

Methodist Health System

Code:

NCT06223607

Conditions

Baseline Thrombocytopenia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The use of clopidogrel as part of DAPT will be associated with lower bleeding rates compared to ticagrelor in patients with chronic thrombocytopenia requiring Percutaneous intervention (PCI )with Drug Eluting Stent (DES) or Bare Metal Stint(BMS).

Conditions

Baseline Thrombocytopenia

Study ID

NCT06223607

Start date

Aug 22, 2022

Status verified date

Jan, 2026

Completion date

Dec 22, 2027

Anticipated

Primary completion date

Dec 28, 2026

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

≥ 18 years
PCI with either DES or BMS during study time period (April 1, 2018 through July 1 2021)
Thrombocytopenia defined as platelet count <100 x103 /µL on at least one occasion prior to PCI
At least one dose of DAPT post-PCI with aspirin and either clopidogrel or ticagrelor

Exclusion Criteria:

Death within 48 hours post-PCI
DAPT prior to cardiac catheterization

Study Design

Enrollment

300 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

Incidence of bleeding [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Bethany Brauer

214-947-4681 mhsirb@mhd.com

Colette Ngo Ndjom

214-947-1289 mhsirb@mhd.com

Locations

Methodist Dallas Medical Center

Recruiting

Dallas, Texas, United States, 75203

Contacts

Colette Ngo Ndjom

214-947-4681 mhsirb@mhd.com

Bethany Brauer

214-947-4681 mhsirb@mhd.com

Principal Investigator:

Jessica Rago Crotty, Pharm D

More Information

Sponsor

Methodist Health System

Last update posted

Jun 10, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Methodist Health System on 2026-06-10.