Recruiting

Topical Treatment

Sponsor:

Wake Forest University Health Sciences

Code:

NCT06244212

Conditions

Atopic Dermatitis

Eligibility Criteria

Sex: All

Age: 9+

Healthy Volunteers: Not accepted

Interventions

Demonstration of applying triamcinolone cream

Mobile App Use

Standard of Care

Study Details

Brief summary:

Medication adherence is a poorly studied phenomenon that challenges both patients and physicians. 50% of individuals with chronic disease are not adherent to their medication regimen. Within the United States, non-adherence to medical treatment leads to approximately $100 billion in hospital admission costs. While the issue of adherence is not limited to any particular field of medicine, non-adherence occurs in approximately one-third to one-half of dermatological patients. Non-adherence is of importance as it is a significant cause of treatment failure, resulting in worse quality of life, worse health outcomes, and increased insurance costs.

Conditions

Atopic Dermatitis

Study ID

NCT06244212

Start date

Sep 19, 2024

Status verified date

Aug, 2026

Completion date

Nov, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 9+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of skin dermatitis
  • Age > 9
  • Ability to return for a one-week clinical studies follow-up
  • Patients who are candidates for treatment with 0.1% triamcinolone ointment (even if they weren't in the study)
  • Adult or pediatric patients with active dermatitis who receive dermatologic care at Atrium Health Wake Forest Baptist, Department of Dermatology.

Exclusion Criteria:

  • Patients without the diagnosis of skin dermatitis
  • Inability to return for a one week follow up appointment
  • Body Surface Area (BSA) affected <2%

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

active comparator: Demonstration

Observe a live demonstration instructing how to dispense 1 fingertip unit (FTU) of medication (triamcinolone cream) per 1% body surface area

experimental: Mobile Application

Additional mobile application that provides instructions to apply the medication (triamcinolone cream)

other: Written/verbal instructions only

Standard of care written/verbal instructions only

Interventions

Demonstration of applying triamcinolone cream

Live demonstration of applying 1 fingertip unit of triamcinolone cream

Mobile App Use

Additional mobile application that provides amount dispensed and adherence data.

Standard of Care

Written/verbal instructions only

Primary outcome measure

  • Amount of Topical Medication Dispensed - Demonstration Group [ Time Frame: Day 7 ]
  • Amount of Topical Medication Dispensed - Standard of Care Group [ Time Frame: Day 7 ]
  • Amount of Topical Medication Dispensed - Mobile Application Group [ Time Frame: Day 7 ]
  • Number of times of Application - Demonstration Group [ Time Frame: Day 7 ]
  • Number of times of Application - Standard of Care Group [ Time Frame: Day 7 ]
  • Number of times of Application - Mobile Application Group [ Time Frame: Day 7 ]
  • Change in Investigator Global Assessment (IGA) Scores [ Time Frame: Baseline and Day 7 ]
  • Change in Percentage of Body Surface Area (BSA) affected [ Time Frame: Baseline and Day 7 ]
  • Subject Questionnaire Scores [ Time Frame: Day 7 ]

Central Contacts and Locations

Central contacts

Irma Richardson, MHA

336.716.2903irichard@wakehealth.edu

Locations

Wake Forest University Health Sciences

Recruiting

Winston-Salem, North Carolina, United States, 27157

Contacts

Irma Richardson, MHA

336-716-2903irichard@wakehealth.edu

Principal Investigator:

Steven R Feldman, MD, PhD

More Information

Sponsor

Wake Forest University Health Sciences

Last update posted

Aug 4, 2026

Last verified

Aug, 2026

Keywords

  • Medication adherence
  • topical medications
  • Triamcinolone

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Wake Forest University Health Sciences on 2026-08-04.