Recruiting

Observational Study

Sponsor:

Temple University

Code:

NCT06257433

Conditions

Motivation

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Task Instructions

Study Details

Brief summary:

Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.

Conditions

Motivation

Study ID

NCT06257433

Start date

Oct 24, 2023

Status verified date

Aug, 2025

Completion date

Aug 1, 2026

Anticipated

Primary completion date

Aug 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 20/40 far acuity (either corrected or uncorrected)
  • In good medical health

Exclusion Criteria:

  • History of head injury
  • History of illness with Central Nervous Systems implications
  • On Medications that Affect blood flow response and alertness
  • Consumption of smoking and/or coffee 30 minutes prior to laboratory testing
  • Placement of a device contraindicated for magnetic resonance imaging including cardia pacemaker, aneurysm clip, cochlear implants, pregnancy, intra-uterine device, shrapnel, metal fragments in the eyes, neurostimulators
  • Weight > 250lbs
  • Claustrophobia

Study Design

Enrollment

80 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Motivation

Trials in which participants are motivated by hypothesis testing or not.

Interventions

Task Instructions

Participants will be given cued instructions as to whether they are in a high or low motivation condition

Primary outcome measure

  • Mesolimbic Hippocampal Interactions [ Time Frame: During Procedure ]
  • Episodic Memory [ Time Frame: 24-hours After Procedure ]

Central Contacts and Locations

Central contacts

Vishnu Murty, PhD

7406328932vishnu.murty@temple.edu

Locations

Temple University

Recruiting

Philadelphia, Pennsylvania, United States, 19122

Contacts

Vishnu P Murty

7406328932vishnu.murty@temple.edu

Principal Investigator:

Vishnu P Murty, PhD

More Information

Sponsor

Temple University

Last update posted

Sep 5, 2025

Last verified

Aug, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Temple University on 2025-09-05.