Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT06261034

Conditions

Obstructive Sleep Apnea

Eligibility Criteria

Sex: All

Age: 20 - 70

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).

Conditions

Obstructive Sleep Apnea

Study ID

NCT06261034

Start date

Oct 29, 2024

Status verified date

Jan, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 70

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 20-70 years of age

Exclusion Criteria:

  • Coronary artery disease
  • Heart failure
  • Pregnancy
  • COPD
  • Diabetes
  • CKD
  • Sleep disorders other than OSA
  • Shift workers
  • Individuals who typically go to sleep after midnight
  • Individuals who traveled across ≥2 time zones within one week of study visits
  • BMI ≥40.0kg/m2
  • Use of nicotine-containing products within the two years preceding study visits
  • Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with outcome measures

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Blood pressure [ Time Frame: Baseline ]
  • Arterial stiffness [ Time Frame: Baseline ]
  • Endothelial function [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Joshua Bock, PhD

(507) 422-0768Bock.Joshua@mayo.edu

Ian Greenlund, PhD

(507) 422-3411Greenlund.Ian@mayo.edu

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Joshua Bock, PhD

(507) 422-0768bock.joshua@mayo.edu

Ian Greenlund, PhD

(507) 422-3411Greenlund.Ian@mayo.edu

Principal Investigator:

Joshua Bock, PhD

More Information

Sponsor

Mayo Clinic

Last update posted

Jan 7, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-01-07.